Bio-Products Laboratory, Central Leather Research Institute (CLRI), Adyar, Chennai 600 020, India.
Nanoscale. 2015 Jun 7;7(21):9676-85. doi: 10.1039/c5nr00113g.
Recently, bioretention and toxicity of injected nanoparticles in the body has drawn much attention in biomedical research. In the present study, 5 mg Fe per kg body weight of magnetic fibrin nanoparticles (MFNPs) were injected into mice intravenously and investigated for their blood clearance profile, biodistribution, haematology and pathology studies for a time period of 28 days. Moderately long circulation of MFNPs in blood was observed with probable degradation and excretion into the bloodstream via monoatomic iron forms. Inductively coupled plasma optical emission spectrometry (ICP-OES) and Prussian blue staining results showed increased accumulation of MFNPs in the liver, followed by spleen and other organs. Body weight, spleen/thymus indexes, haematology, serum biochemistry and histopathology studies demonstrated that MFNPs were biocompatible. These results suggest the feasibility of using MFNPs for drug delivery and imaging applications.
最近，生物滞留和注入体内的纳米粒子的毒性在生物医学研究中引起了广泛关注。在本研究中，将 5mg Fe/kg 体重的磁性纤维蛋白纳米粒子（MFNPs）静脉内注射到小鼠体内，研究其血液清除曲线、生物分布、血液学和病理学研究 28 天。MFNPs 在血液中具有中等循环时间，可能通过单原子铁形式降解并排泄到血液中。电感耦合等离子体发射光谱（ICP-OES）和普鲁士蓝染色结果表明，MFNPs 在肝脏中的积累增加，随后是脾脏和其他器官。体重、脾/胸腺指数、血液学、血清生化和组织病理学研究表明 MFNPs 具有生物相容性。这些结果表明，MFNPs 可用于药物输送和成像应用。
