电诱发多重放电与运动神经元病更明显的临床恶化相关。
Electrically evoked multiplet discharges are associated with more marked clinical deterioration in motor neuron disease.
作者信息
Sleutjes Boudewijn T H M, Maathuis Ellen M, van Doorn Pieter A, Blok Joleen H, Visser Gerhard H
机构信息
Department of Clinical Neurophysiology, University Medical Centre Rotterdam, P.O. Box 2040, 3000, CA Rotterdam, The Netherlands.
Department of Neurology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
出版信息
Muscle Nerve. 2016 Feb;53(2):222-6. doi: 10.1002/mus.24700. Epub 2015 Dec 9.
INTRODUCTION
The aim of this study was to determine whether electrically evoked multiplet discharges (MDs) are related to severity of clinical deterioration in motor neuron disease (MND).
METHODS
Stimulated high-density surface electromyographic (HDsEMG) recordings were performed in thenar muscles. Data were collected from 31 MND patients. MDs from the HDsEMG recordings were determined at baseline. ALSFRS-R scores were obtained at baseline and at a maximum of 16 weeks follow-up.
RESULTS
The presence of MDs was associated with progressive deterioration of ALSFRS-R score (P = 0.02) and fine motor function (FMF) (P < 0.001). Patients who had a higher number of motor units that generated MDs (r = 0.61, P < 0.001) and patients who had a higher number of MDs (as percentage of applied stimuli) (r = 0.59, P = 0.001) had a more severe decline in FMF.
CONCLUSIONS
Electrically evoked MDs are associated with more marked clinical deterioration in patients with MND.
引言
本研究旨在确定电诱发多峰放电（MDs）是否与运动神经元病（MND）临床恶化的严重程度相关。
方法
对大鱼际肌进行刺激高密度表面肌电图（HDsEMG）记录。收集了31例MND患者的数据。在基线时确定HDsEMG记录中的MDs。在基线时以及最多16周的随访时获得肌萎缩侧索硬化功能评分修订版（ALSFRS-R）分数。
结果
MDs的存在与ALSFRS-R评分（P = 0.02）和精细运动功能（FMF）的进行性恶化相关（P < 0.001）。产生MDs的运动单位数量较多的患者（r = 0.61，P < 0.001）以及MDs数量较多（占施加刺激的百分比）的患者（r = 0.59，P = 0.001）的FMF下降更严重。
结论
电诱发的MDs与MND患者更明显的临床恶化相关。
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