识别运动神经元疾病中的肌束震颤电位：一个概率问题。

Identifying fasciculation potentials in motor neuron disease: A matter of probability.

作者信息

Sleutjes Boudewijn T H M, Gligorijević Ivan, Montfoort Inger, van Doorn Pieter A, Visser Gerhard H, Blok Joleen H

机构信息

Department of Clinical Neurophysiology, Erasmus MC, University Medical Centre Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

Department of Electrical Engineering, SCD-SISTA, KU Leuven, Belgium.

出版信息

Muscle Nerve. 2016 Feb;53(2):227-33. doi: 10.1002/mus.24712. Epub 2015 Oct 10.

DOI:10.1002/mus.24712

PMID:26012503

Abstract

INTRODUCTION

Fasciculations, the spontaneous activity of single motor units (MUs) are characteristic, but nonspecific for motor neuron disease (MND). We aimed to identify MU discharge properties to optimally differentiate MND patients from healthy controls.

METHODS

High-density surface electromyography recordings were performed in the thenar muscles during 10 min of rest. MU discharges were classified as "isolated" when the interspike intervals (ISIs) before and after were > 250 ms, "continual" when both ISIs were ≤ 250 ms, or as "other".

RESULTS

In patients (n = 30) compared with controls (n = 14), more MUs were active (9 vs. 3, P < 0.001) and generated relatively more isolated discharges (35% vs. 10%, P = 0.01). Two or more MUs with isolated discharges occurred more frequently in patients compared with controls (24% vs. <1% of 10-s windows, P < 0.001).

CONCLUSIONS

More frequent occurrence of multiple MUs showing isolated discharges may improve identification of patients with MND.

摘要

引言

肌束震颤，即单个运动单位（MU）的自发活动，是运动神经元病（MND）的特征性表现，但并非特异性表现。我们旨在确定运动单位放电特性，以最佳区分MND患者与健康对照者。

方法

在休息10分钟期间，对鱼际肌进行高密度表面肌电图记录。当前后峰间期（ISI）>250毫秒时，运动单位放电被分类为“孤立性”；当两个ISI均≤250毫秒时，分类为“连续性”；或其他分类。

结果

与对照组（n = 14）相比，患者组（n = 30）中有更多的运动单位处于活动状态（9个对3个，P < 0.001），并且产生相对更多的孤立性放电（35%对10%，P = 0.01）。与对照组相比，患者组中出现两个或更多孤立性放电运动单位的频率更高（24%对10秒窗口的<1%，P < 0.001）。