Pan Qingjun, Gao Caina, Chen Yanwen, Feng Yongmin, Liu Wei Jing, Liu Hua-feng
Institute of Nephrology, Affiliated Hospital of Guangdong Medical College, Zhanjang 524001, China.
Biomed Pharmacother. 2015 Apr;71:190-3. doi: 10.1016/j.biopha.2015.02.017. Epub 2015 Feb 26.
Systemic lupus erythematosus (SLE), induced by the interaction of susceptibility genes and environment risk factors, is a classical autoimmune diseases characterized by the dysregulation of innate and adaptive immune systems. Recently, evidence from genetic, cell biology and animal models suggested autophagy, a major pathway for organelle and protein turnover, plays a pivotal role in the occurrence and development of SLE, but not yet fully elucidated. We summarized an update on the recognized key principles of autophagy in SLE and focused our attention on the role of autophagy, including two main signaling pathways including mTOR and Beclin-1, in immune cells, such as B cell, T cell, neutrophils, etc. in SLE. Also, effects of currently used biological and chemical therapeutic drugs on autophagy in SLE were discussed. Autophagy may provide new targets for both diagnostic and therapeutic approaches for SLE although some results are still controversial, which worth more in-depth discussion in the future.
系统性红斑狼疮（SLE）是由易感基因与环境风险因素相互作用诱发的一种经典自身免疫性疾病，其特征为固有免疫系统和适应性免疫系统失调。最近，来自遗传学、细胞生物学和动物模型的证据表明，自噬作为细胞器和蛋白质周转的主要途径，在SLE的发生和发展中起关键作用，但尚未完全阐明。我们总结了SLE中自噬公认关键原则的最新进展，并将注意力集中在自噬在SLE免疫细胞（如B细胞、T细胞、中性粒细胞等）中的作用，包括mTOR和Beclin-1这两条主要信号通路。此外，还讨论了目前使用的生物和化学治疗药物对SLE自噬的影响。尽管一些结果仍存在争议，但自噬可能为SLE的诊断和治疗方法提供新的靶点，值得未来进行更深入的讨论。
