SOD Medical Pathology, Center for Autoimmune Systemic Diseases, Behcet Center and Lupus Clinic, AOU Careggi, Florence, Italy.
Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):585-96. doi: 10.1177/039463201302600302.
Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases with multiorgan involvement. SLE presents many genetic and epigenetic associations and the pathogenesis is characterized by a complex network of alterations affecting both adaptative and innate immunity. The disclosure of novel mechanisms of SLE pathogenesis suggested new therapeutic targets, based on interference with the cytokine pathways or on depletion of the immune cells.
系统性红斑狼疮（SLE）是多器官受累自身免疫性疾病的原型。SLE 存在许多遗传和表观遗传关联，其发病机制的特征是影响适应性和先天免疫的复杂网络改变。SLE 发病机制新机制的揭示为基于细胞因子途径干扰或免疫细胞耗竭的新型治疗靶点提供了依据。
