Sakadžić Sava, Lee Jonghwan, Boas David A, Ayata Cenk
Optics Division, MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Optics Division, MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Brain Res. 2015 Oct 14;1623:174-92. doi: 10.1016/j.brainres.2015.04.044. Epub 2015 May 8.
Central nervous system (CNS) function and dysfunction are best understood within a framework of interactions between neuronal, glial and vascular compartments comprising the neurovascular unit (NVU), all of which contribute to stroke-induced CNS injury, plasticity, repair, and recovery. Recent advances in in vivo optical microscopy have enabled us to observe and interrogate cells and their processes with high spatial resolution in real time and in their natural environment deep in the brain tissue. Here, we review some of these state-of-the-art imaging techniques with an emphasis on imaging the interactions among the constituents of the NVU during ischemic injury and repair in small animal models. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.
中枢神经系统（CNS）的功能与功能障碍，在由神经血管单元（NVU）组成的神经元、神经胶质和血管区室之间相互作用的框架内最易理解，所有这些都与中风引起的中枢神经系统损伤、可塑性、修复及恢复有关。体内光学显微镜的最新进展使我们能够在脑组织深处的自然环境中，以高空间分辨率实时观察和研究细胞及其活动过程。在此，我们回顾其中一些最先进的成像技术，重点是在小动物模型的缺血性损伤和修复过程中，对神经血管单元各组成部分之间的相互作用进行成像。本文是名为“SI：中风中的细胞相互作用”特刊的一部分。
