Yi Zhang, Shao-Long Yang, Ai-Hong Wang, Zhi-Chun Sun, Ya-Fen Zhuo, Ye-Ting Xu, Yu-Ling He
Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, China.
Department of Pathology, Zhengzhou Railway Vocational and Technical College, Zhengzhou, Henan 450000, China.
Evid Based Complement Alternat Med. 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16.
We investigated the effects of Hericium erinaceus (HEE) on alloxan induced diabetic neuropathic pain in laboratory rats. Alloxan induced diabetic rats were administered orally HEE. After 6 weeks of treatments, treatment with HEE 40 mg/kg in diabetic animals showed significant increase in pain threshold and paw withdrawal threshold and significant decrease in serum glucose and urine glucose. We also observed a significant increase in lactate dehydrogenase (LDH), Lipid peroxidation (LPO), glutathione peroxidase (GPx) activity, glutathione reductase (GR) activity, catalase (CAT) activity, Na(+)K(+)ATPase activity, and glutathione S transferase (GST) activity along with significant decreased levels of glutathione (GSH) content in diabetic rats. The total antioxidant status (TAOS) in the HEE-treated groups was significantly lower than that in the alloxan-treated group. HEE can offer pain relief in diabetic neuropathic pain. The improvement in diabetic state after HEE treatment along with the antioxidant activity could be the probable way by which it had alleviated diabetic neuropathy.
我们研究了猴头菌（HEE）对四氧嘧啶诱导的实验性糖尿病大鼠神经病理性疼痛的影响。给四氧嘧啶诱导的糖尿病大鼠口服HEE。治疗6周后，糖尿病动物给予40mg/kg的HEE治疗，疼痛阈值和爪部撤离阈值显著升高，血清葡萄糖和尿糖显著降低。我们还观察到糖尿病大鼠的乳酸脱氢酶（LDH）、脂质过氧化（LPO）、谷胱甘肽过氧化物酶（GPx）活性、谷胱甘肽还原酶（GR）活性、过氧化氢酶（CAT）活性、钠钾ATP酶（Na(+)K(+)ATPase）活性和谷胱甘肽S转移酶（GST）活性显著增加，同时谷胱甘肽（GSH）含量显著降低。HEE治疗组的总抗氧化状态（TAOS）显著低于四氧嘧啶治疗组。HEE可以缓解糖尿病神经病理性疼痛。HEE治疗后糖尿病状态的改善以及抗氧化活性可能是其缓解糖尿病神经病变的可能途径。
