Chen Zhiye, Lou Xin, Liu Mengqi, Huang Dehui, Wei Shihui, Yu Shengyuan, Ma Lin
Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China; Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China.
Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
PLoS One. 2015 May 11;10(5):e0126574. doi: 10.1371/journal.pone.0126574. eCollection 2015.
Diffusion tensor imaging (DTI) has been used for the evaluation of the white matter integrity. In this study, we evaluated optic nerve impairment in patients with neuromyelitis optica (NMO) using DTI.
METHODOLOGY/PRINCIPAL FINDINGS: Optic nerve DTI were performed on 28 NMO patients and 38 normal controls. Fractional anisotropy (FA) values were measured in the anterior, middle, and posterior parts of the intraorbital optic nerve segment. For the posterior intraorbital optic nerve, FA values of BI (0.20±0.07), MI (0.24±0.16), and NA (0.25±0.14) decreased significantly compared with that of NC (0.43±0.07) (P<0.05), and ROC analysis demonstrated that the area under the curve (AUC) measurements for BI vs. NC, MI vs. NC, NA vs. NC, and NMO (including BI, MI, and NA) vs. NC were 0.99, 0.93, 0.88, and 0.96, respectively. The corresponding diagnostic sensitivities of ROC analysis were 100%, 80%, 80%, and 91%; and the specificities were 93%, 97%, 91%, and 93%.
CONCLUSIONS/SIGNIFICANCE: Decreased FA value in the intraorbital optic nerve, especially in the posterior part of the nerve, was demonstrated as a characteristic MR feature for NMO-related optic nerve impairment.
扩散张量成像（DTI）已被用于评估白质完整性。在本研究中，我们使用DTI评估视神经脊髓炎（NMO）患者的视神经损伤情况。
方法/主要发现：对28例NMO患者和38例正常对照者进行视神经DTI检查。测量眶内视神经段前部、中部和后部的分数各向异性（FA）值。对于眶内视神经后部，与正常对照（NC，0.43±0.07）相比，双侧（BI，0.20±0.07）、中间（MI，0.24±0.16）和鼻侧（NA，0.25±0.14）的FA值显著降低（P<0.05），ROC分析表明，BI与NC、MI与NC、NA与NC以及NMO（包括BI、MI和NA）与NC比较的曲线下面积（AUC）测量值分别为0.99、0.93、0.88和0.96。ROC分析相应的诊断敏感性分别为100%、80%、80%和91%；特异性分别为93%、97%、91%和93%。
结论/意义：眶内视神经FA值降低，尤其是神经后部，是NMO相关视神经损伤的特征性磁共振表现。
