Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Canada.
International Centre for Migration, Health and Development, Geneva, Switzerland.
J Hepatol. 2015 Aug;63(2):515-22. doi: 10.1016/j.jhep.2015.04.026. Epub 2015 May 8.
WHO estimates reveal that the global prevalence of viral hepatitis may be as high as 500 million, with an annual mortality rate of up to 1.3 million individuals. The majority of this global burden of disease is borne by nations of the developing world with high rates of vertical and iatrogenic transmission of HBV and HCV, as well as poor access to healthcare. In 2013, 3.2% of the global population (231 million individuals) migrated into a new host nation. Migrants predominantly originate from the developing countries of the south, into the developed economies of North America and Western Europe. This mass migration of individuals from areas of high-prevalence of viral hepatitis poses a unique challenge to the healthcare systems of the host nations. Due to a lack of universal standards for screening, vaccination and treatment of viral hepatitis, the burden of chronic liver disease and hepatocellular carcinoma continues to increase among migrant populations globally. Efforts to increase case identification and treatment among migrants have largely been limited to small outreach programs in urban centers, such that the majority of migrants with viral hepatitis continue to remain unaware of their infection. This review summarizes the data on prevalence of viral hepatitis and burden of chronic liver disease among migrants, current standards for screening and treatment of immigrants and refugees, and efforts to improve the identification and treatment of viral hepatitis among migrants.
世界卫生组织估计,全球病毒性肝炎的流行率可能高达 5 亿,年死亡率高达 130 万人。这些疾病负担主要集中在发展中国家,这些国家乙肝和丙肝的母婴垂直传播和医源性传播率高,而且医疗保健的可及性较差。2013 年,全球有 3.2%的人口(2.31 亿人)迁移到新的居住国。移民主要来自南方发展中国家,进入北美和西欧的发达经济体。大量来自高病毒性肝炎流行地区的人迁移到这些地区,这给宿主国家的医疗保健系统带来了独特的挑战。由于缺乏筛查、疫苗接种和治疗病毒性肝炎的普遍标准,慢性肝病和肝细胞癌的负担在全球移民群体中继续增加。增加移民病例识别和治疗的努力主要局限于城市中心的小型外展计划,以至于大多数患有病毒性肝炎的移民仍然不知道自己被感染。本文综述了移民中病毒性肝炎的流行率和慢性肝病负担的数据、移民和难民筛查和治疗的现行标准,以及提高移民中病毒性肝炎识别和治疗的努力。