韩国儿童炎症性肠病的特征：与欧洲儿童炎症性肠病（EUROKIDS）数据的比较
Characteristics of Pediatric Inflammatory Bowel Disease in Korea: Comparison with EUROKIDS Data.
作者信息
Lee Hyeon Ah, Suk Jung Yoon, Choi Sung Youn, Kim Eun Ran, Kim Young-Ho, Lee Chang Kyun, Huh Kyu Chan, Lee Kang Moon, Park Dong Il
机构信息
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
Gut Liver. 2015 Nov 23;9(6):756-60. doi: 10.5009/gnl14338.
BACKGROUND/AIMS: Pediatric inflammatory bowel disease (IBD) has been increasing worldwide. The characteristics of pediatric-onset IBD have mainly been reported in Western countries. We investigated the clinical characteristics of pediatric IBD in Korea and compared these with the data from the 5-year European multicenter study of children with new-onset IBD (EUROKIDS registry).
METHODS
Children who were diagnosed with IBD between July 1987 and January 2012 were investigated at five Korean university hospitals. Their clinical characteristics were retrospectively evaluated by medical record review. The results were compared with the EUROKIDS data.
RESULTS
A total of 30 children with Crohn's disease (CD) and 33 children with ulcerative colitis (UC) were enrolled. In comparison with the EUROKIDS group, Korean pediatric IBD patients showed a male predominance (86.7% vs 59.2%, p=0.002 in CD; 75.8% vs 50%, p=0.003 in UC). Korean pediatric CD patients had a higher prevalence of terminal ileal disease (36.7% vs 16.3%, p=0.004) and perianal disease (33.3% vs 8.2%, p<0.001) than patients in the EUROKIDS group. Korean pediatric UC patients had a higher prevalence of proctitis than patients in the EUROKIDS group.
CONCLUSIONS
Our results suggest that the characteristics of Korean pediatric IBD patients and European pediatric IBD patients may be different.
背景/目的：小儿炎症性肠病（IBD）在全球范围内呈上升趋势。小儿起病的IBD特征主要在西方国家报道。我们调查了韩国小儿IBD的临床特征，并将其与欧洲一项针对新发IBD儿童的5年多中心研究（EUROKIDS注册研究）的数据进行比较。
方法
对1987年7月至2012年1月期间在韩国五所大学医院被诊断为IBD的儿童进行调查。通过病历回顾对他们的临床特征进行回顾性评估。将结果与EUROKIDS数据进行比较。
结果
共纳入30例克罗恩病（CD）患儿和33例溃疡性结肠炎（UC）患儿。与EUROKIDS组相比，韩国小儿IBD患者以男性为主（CD组中分别为86.7%对59.2%，p = 0.002；UC组中分别为75.8%对50%，p = 0.003）。韩国小儿CD患者末端回肠疾病（36.7%对16.3%，p = 0.004）和肛周疾病（33.3%对8.2%，p<0.001）的患病率高于EUROKIDS组患者。韩国小儿UC患者直肠炎的患病率高于EUROKIDS组患者。
结论
我们的结果表明，韩国小儿IBD患者和欧洲小儿IBD患者的特征可能有所不同。
Zotero 插件