Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
Sci Rep. 2020 Nov 4;10(1):19032. doi: 10.1038/s41598-020-75938-1.
In pediatric Crohn's disease (CD) patients, it is important to define the disease phenotype at diagnosis for stratifying risk. In this retrospective study, we aimed to assess the disease phenotype compared to EUROKIDS registry and analyze disease outcome of pediatric CD patients according to upper gastrointestinal (GI) tract involvement. A total of 312 patients were included. The median age at diagnosis was 13.7 years and 232 patients (74.4%) were identified to have upper GI involvement at diagnosis. In Korean pediatric CD patients, there were significant differences in male predominance (72.8% vs. 59.2, p < 0.001), proportion of upper GI involvement (74.4% vs. 46.2%, p < 0.001), and perianal disease (62.1% vs. 8.2%, p < 0.001) compared to data in the EUROKIDS registry. Younger age (OR 2.594, p = 0.0139) and ileal involvement (OR 2.293, p = 0.0176) at diagnosis were associated with upper GI involvement. There were no significant differences in disease outcomes between patients with and without upper GI tract involvement. This study revealed that upper GI involvement is more prevalent in Korean patients with pediatric Crohn's disease than in European patients, and the disease outcome did not appear to differ according to upper GI tract involvement.
在儿科克罗恩病 (CD) 患者中，重要的是在诊断时确定疾病表型，以进行风险分层。在这项回顾性研究中，我们旨在评估与 EUROKIDS 登记处相比的疾病表型，并根据上消化道 (GI) 道受累分析儿科 CD 患者的疾病结局。共纳入 312 例患者。诊断时的中位年龄为 13.7 岁，232 例 (74.4%) 患者在诊断时被确定有上 GI 受累。在韩国儿科 CD 患者中，男性优势（72.8% 比 59.2%，p<0.001）、上 GI 受累比例（74.4% 比 46.2%，p<0.001）和肛周疾病（62.1% 比 8.2%，p<0.001）与 EUROKIDS 登记处的数据存在显著差异。诊断时年龄较小（OR 2.594，p=0.0139）和回肠受累（OR 2.293，p=0.0176）与上 GI 受累相关。有上 GI 道受累和无上 GI 道受累的患者之间疾病结局无显著差异。这项研究表明，与欧洲患者相比，上 GI 受累在韩国儿科 CD 患者中更为常见，并且疾病结局似乎不受上 GI 道受累的影响。
