National Centre for Paediatric Gastroenterology, Hepatology and Nutrition, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland.
Arch Dis Child. 2012 Jul;97(7):590-4. doi: 10.1136/archdischild-2011-300651. Epub 2012 May 1.
To describe the change in incidence of paediatric inflammatory bowel disease (IBD) observed at the National Centre for Paediatric Gastroenterology, Hepatology and Nutrition, and to determine whether the presenting disease phenotype and disease outcomes have changed during the past decade.
The annual incidence of IBD in Irish children aged <16 years was calculated for the years 2000-2010. Two subsets of patients, group A (diagnosed between 1 January 2000 and 31 December 2001), and group B (diagnosed between 1 January and 31 December 2008) were phenotyped according to the Paris Classification. Phenotype at diagnosis and 2-year follow-up were then compared.
406 new cases of IBD were identified. The incidence was 2.5/100 000/year in 2001, 7.3 in 2008 and 5.6 in 2010, representing a significant increase in the number of new cases of Crohn's disease (CD) and ulcerative colitis (UC). There were 238 cases of CD; 129 of UC; and 39 of IBD unclassified. Comparing groups A and B, no differences were found in disease location at diagnosis or, for CD, in its behaviour.
There has been a substantial and sustained increase in the incidence of childhood UC and CD in Ireland over a relatively short period of time. However, disease phenotype at diagnosis has not changed. At 2 years follow-up, CD appears to progress less frequently than in some neighbouring countries. These variations remain unexplained. Prospective longitudinal studies will help to elucidate further the epidemiology of childhood IBD.
描述在国家儿童胃肠病学、肝病学和营养学中心观察到的儿科炎症性肠病（IBD）发病率的变化，并确定在过去十年中，疾病表型和疾病结局是否发生了变化。
计算了 2000-2010 年爱尔兰年龄<16 岁儿童的 IBD 年发病率。根据巴黎分类，将两组患者分为 A 组（2000 年 1 月 1 日至 12 月 31 日诊断）和 B 组（2008 年 1 月 1 日至 12 月 31 日诊断）。然后比较诊断时和 2 年随访时的表型。
共发现 406 例新的 IBD 病例。2001 年发病率为 2.5/100000/年，2008 年为 7.3，2010 年为 5.6，代表克罗恩病（CD）和溃疡性结肠炎（UC）新发病例数显著增加。其中 CD 238 例，UC 129 例，IBD 未分类 39 例。比较 A 组和 B 组，在诊断时疾病部位或 CD 行为方面均无差异。
在相对较短的时间内，爱尔兰儿童 UC 和 CD 的发病率显著且持续增加。然而，诊断时的疾病表型没有改变。在 2 年随访时，CD 似乎比一些邻国进展得更不频繁。这些差异尚无法解释。前瞻性纵向研究将有助于进一步阐明儿童 IBD 的流行病学。
