长期太空飞行后宇航员大脑中的皮质重组。
Cortical reorganization in an astronaut's brain after long-duration spaceflight.
作者信息
Demertzi Athena, Van Ombergen Angelique, Tomilovskaya Elena, Jeurissen Ben, Pechenkova Ekaterina, Di Perri Carol, Litvinova Liudmila, Amico Enrico, Rumshiskaya Alena, Rukavishnikov Ilya, Sijbers Jan, Sinitsyn Valentin, Kozlovskaya Inessa B, Sunaert Stefan, Parizel Paul M, Van de Heyning Paul H, Laureys Steven, Wuyts Floris L
机构信息
Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège, Liège, Belgium.
Antwerp University Research Centre for Equilibrium and Aerospace (AUREA), Antwerp University Hospital and University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium.
出版信息
Brain Struct Funct. 2016 Jun;221(5):2873-6. doi: 10.1007/s00429-015-1054-3. Epub 2015 May 12.
To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients.
迄今为止，暴露于微重力环境后生理功能受到的阻碍主要归因于外周神经感觉系统的缺失。本研究首次阐明了长期太空飞行后人类大脑功能的变化。更具体地说，我们发现运动皮层和小脑之间的静息态功能连接存在显著差异，以及默认模式网络内部的变化。此外，宇航员在运动想象任务期间辅助运动区出现了变化。这些结果突出了太空飞行导致的生理机能失调背后的神经基础，并且与未来的星际任务和前庭疾病患者相关。
Zotero 插件