Chemisches Institut der Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany.
Chem Soc Rev. 2015 Aug 7;44(15):4986-5002. doi: 10.1039/c5cs00088b. Epub 2015 May 12.
This Tutorial Review presents an overview on the synthesis, characterization and applications of metal complexes containing curcumin (=1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) and its derivatives as ligands. Innovative synthetic strategies leading to soluble and crystallizable metal curcumin complexes are outlined in detail. Special emphasis is placed on the highly promising and exciting medicinal applications of metal curcumin complexes, with the three most important areas being anticancer activity and selective cytotoxicity, anti-Alzheimer's disease activity, and antioxidative/neuroprotective effects. Overall, this Tutorial Review provides the first general overview of this emerging and rapidly expanding field of interdisciplinary research.
本教程综述介绍了含姜黄素（= 1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮）及其衍生物作为配体的金属配合物的合成、表征和应用。详细概述了导致可溶性和结晶性金属姜黄素配合物的创新合成策略。特别强调了金属姜黄素配合物在三个最重要的领域中的极具前景和令人兴奋的医学应用，即抗癌活性和选择性细胞毒性、抗阿尔茨海默病活性以及抗氧化/神经保护作用。总的来说，本教程综述提供了对这个新兴的快速发展的跨学科研究领域的首次全面概述。
