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姜黄素席夫碱、腙和肟衍生物的生物活性综述。

A review on biological activities of Schiff base, hydrazone, and oxime derivatives of curcumin.

作者信息

Omidi Sakineh, Kakanejadifard Ali

机构信息

Department of Chemistry, Faculty of Science, Lorestan University Khorramabad Iran

出版信息

RSC Adv. 2020 Aug 17;10(50):30186-30202. doi: 10.1039/d0ra05720g. eCollection 2020 Aug 10.

DOI:10.1039/d0ra05720g
PMID:35518272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9056295/
Abstract

Curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) is the main pigment present in the turmeric rhizome and shows various biological properties. The synthesis of different derivatives is an effective way to improve the medicinal and biological properties of curcumin. Many researchers have chosen the carbonyl group of curcumin for modification and preparation of new analogues. This review critically surveys a general overview of the literature and summarizes the synthesis and biological activities of Schiff base, hydrazone and oxime derivatives of curcumin over the last decade. These compounds and also their metal complexes possess higher potency in biological activity.

摘要

姜黄素（1,7-双[4-羟基-3-甲氧基苯基]-1,6-庚二烯-3,5-二酮）是姜黄根茎中的主要色素，具有多种生物学特性。合成不同的衍生物是改善姜黄素药用和生物学特性的有效途径。许多研究人员选择对姜黄素的羰基进行修饰，以制备新的类似物。这篇综述批判性地审视了文献的总体概况，并总结了过去十年中姜黄素席夫碱、腙和肟衍生物的合成及生物活性。这些化合物及其金属配合物在生物活性方面具有更高的效力。

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