Wilson Christopher B, Karp Christopher L
Global Health Program, Bill & Melinda Gates Foundation, 500 Fifth Avenue North, Seattle, WA 98109, USA
Global Health Program, Bill & Melinda Gates Foundation, 500 Fifth Avenue North, Seattle, WA 98109, USA.
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0152.
Vaccines are one of the most impactful and cost-effective public health measures of the twentieth century. However, there remain great unmet needs to develop vaccines for globally burdensome infectious diseases and to allow more timely responses to emerging infectious disease threats. Recent advances in the understanding of immunological principles operative not just in model systems but in humans in concert with the development and application of powerful new tools for profiling human immune responses, in our understanding of pathogen variation and evolution, and in the elucidation of the structural aspects of antibody-pathogen interactions, have illuminated pathways by which these unmet needs might be addressed. Using these advances as foundation, we herein present a conceptual framework by which the discovery, development and iterative improvement of effective vaccines for HIV, malaria and other globally important infectious diseases might be accelerated.
疫苗是20世纪最具影响力且成本效益最高的公共卫生措施之一。然而，在开发针对全球负担沉重的传染病的疫苗以及更及时地应对新出现的传染病威胁方面，仍存在巨大的未满足需求。不仅在模型系统中，而且在人类中，对免疫原理理解的最新进展，与用于分析人类免疫反应的强大新工具的开发和应用、我们对病原体变异和进化的理解以及对抗体 - 病原体相互作用结构方面的阐明相结合，揭示了满足这些未满足需求的途径。以这些进展为基础，我们在此提出一个概念框架，通过该框架可以加速针对艾滋病毒、疟疾和其他全球重要传染病的有效疫苗的发现、开发和迭代改进。
