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发展中世界有效疫苗面临的生物学挑战。

Biological challenges to effective vaccines in the developing world.

作者信息

Grassly Nicholas C, Kang Gagandeep, Kampmann Beate

机构信息

Department of Infectious Disease Epidemiology, Imperial College London, St Mary's Hospital, Norfolk Place, London W2 1PG, UK The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004, India

The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004, India.

出版信息

Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0138.

DOI:10.1098/rstb.2014.0138
PMID:25964451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4527384/
Abstract

The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue reviews the performance of vaccines in challenging environments, summarizes current thinking on the reasons why vaccines underperform and considers what approaches are necessary to understand the heterogeneity in responses and to improve vaccine immunogenicity and efficacy.

摘要

召开会议讨论疫苗面临的生物学挑战，原因很简单：并非所有疫苗在所有情况下都能同样有效发挥作用。本期特刊回顾了疫苗在具有挑战性环境中的表现，总结了目前对于疫苗效果不佳原因的看法，并思考需要采取哪些方法来理解反应的异质性，以及提高疫苗的免疫原性和效力。

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本文引用的文献

1
Vaccines against enteric infections for the developing world.针对发展中世界的肠道感染疫苗。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2015.0142.
2
Searching for the human genetic factors standing in the way of universally effective vaccines.寻找阻碍通用有效疫苗研发的人类遗传因素。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0341.
3
Systems vaccinology: a promise for the young and the poor.系统疫苗学：给年轻人和穷人带来的希望。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0340.
4
Can immunological principles and cross-disciplinary science illuminate the path to vaccines for HIV and other global health challenges?免疫学原理和跨学科科学能否为攻克艾滋病疫苗及应对其他全球健康挑战指明方向？
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0152.
5
Delivering vaccines to the people who need them most.将疫苗送到最需要的人手中。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0150.
6
Factors influencing innate immunity and vaccine responses in infancy.影响婴儿期先天免疫和疫苗反应的因素。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0148.
7
Vaccinology in the era of high-throughput biology.高通量生物学时代的疫苗学。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0146.
8
Potential for use of retinoic acid as an oral vaccine adjuvant.视黄酸作为口服疫苗佐剂的应用潜力。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0145.
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Probiotics, antibiotics and the immune responses to vaccines.益生菌、抗生素与对疫苗的免疫反应
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Exploring the role of environmental enteropathy in malnutrition, infant development and oral vaccine response.探索环境性肠病在营养不良、婴儿发育及口服疫苗反应中的作用。
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