发展中世界有效疫苗面临的生物学挑战。
Biological challenges to effective vaccines in the developing world.
作者信息
Grassly Nicholas C, Kang Gagandeep, Kampmann Beate
机构信息
Department of Infectious Disease Epidemiology, Imperial College London, St Mary's Hospital, Norfolk Place, London W2 1PG, UK The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004, India
The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004, India.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0138.
Abstract
The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue reviews the performance of vaccines in challenging environments, summarizes current thinking on the reasons why vaccines underperform and considers what approaches are necessary to understand the heterogeneity in responses and to improve vaccine immunogenicity and efficacy.
摘要
召开会议讨论疫苗面临的生物学挑战，原因很简单：并非所有疫苗在所有情况下都能同样有效发挥作用。本期特刊回顾了疫苗在具有挑战性环境中的表现，总结了目前对于疫苗效果不佳原因的看法，并思考需要采取哪些方法来理解反应的异质性，以及提高疫苗的免疫原性和效力。
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2
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3
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Can immunological principles and cross-disciplinary science illuminate the path to vaccines for HIV and other global health challenges?免疫学原理和跨学科科学能否为攻克艾滋病疫苗及应对其他全球健康挑战指明方向？
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