Coelho Neto José
Divisão de Laboratório, Instituto de Criminalística da Polícia Civil de Minas Gerais, Rua Juiz de Fora, 400, CEP 30180-060 Belo Horizonte, MG, Brazil; Departamento de Física e Química, Pontifícia Universidade Católica de Minas Gerais, Avenida Dom José Gaspar, 500, CEP 30535-901 Belo Horizonte,MG, Brazil.
Forensic Sci Int. 2015 Jul;252:87-92. doi: 10.1016/j.forsciint.2015.04.025. Epub 2015 Apr 27.
Blotter paper is among the most common forms of consumption of new psychotropic substances (NPS), formerly referred as designer drugs. In many cases, users are misled to believe they are taking LSD when, in fact, they are taking newer and less known drugs like the NBOMEs or other substituted phenethylamines. We report our findings in quick testing of blotter papers for illicit substances like NBOMEs and other NPS by taking ATR-FTIR spectra directly from blotters seized on the streets, without any sample preparation. Both sides (front and back) of each blotter were tested. Collected data were analyzed by single- and multi-component spectral matching and submitted to chemometric discriminant analysis. Our results showed that, on 66.7% of the cases analyzed, seized blotters contained one or more types of NBOMEs, confirming the growing presence of this novel substances on the market. Matching IR signals were detected on both or just one side of the blotters and showed variable strength. Although no quantitative analysis was made, detection of these substances by the proposed approach serves as indication of variable and possibly higher dosages per blotter when compared to LSD, which showed to be below the detection limit of the applied method. Blotters containing a mescaline-like compound, later confirmed by GC-MS and LC-MS to be MAL (methallylescaline), a substance very similar to mescaline, were detected among the samples tested. Validity of direct ATR-FTIR testing was confirmed by checking the obtained results against independent GC-MS or LC-MS results for the same cases/samples.
吸墨纸是新型精神活性物质（NPS，以前称为设计药物）最常见的消费形式之一。在许多情况下，使用者被误导认为他们服用的是麦角酸二乙酰胺（LSD），而实际上他们服用的是更新的、不太知名的药物，如N-苄基苯乙胺类（NBOMEs）或其他取代苯乙胺。我们报告了通过直接从街头查获的吸墨纸上采集衰减全反射傅里叶变换红外光谱（ATR-FTIR）来快速检测吸墨纸上是否含有如NBOMEs和其他新型精神活性物质等非法物质的研究结果，无需任何样品制备。对每张吸墨纸的两面（正面和背面）都进行了检测。收集的数据通过单组分和多组分光谱匹配进行分析，并进行化学计量判别分析。我们的结果表明，在分析的66.7%的案例中，查获的吸墨纸含有一种或多种类型的NBOMEs，证实了这种新型物质在市场上的日益增多。在吸墨纸的两面或仅一面检测到了匹配的红外信号，且信号强度各不相同。虽然没有进行定量分析，但与麦角酸二乙酰胺相比，通过所提出的方法检测到这些物质表明每张吸墨纸的剂量可能不同且可能更高，而麦角酸二乙酰胺显示低于所应用方法的检测限。在测试的样品中检测到了含有一种类似三甲氧苯乙胺的化合物的吸墨纸，后来通过气相色谱-质谱联用（GC-MS）和液相色谱-质谱联用（LC-MS）证实该化合物为甲基烯丙基三甲氧苯乙胺（MAL），一种与三甲氧苯乙胺非常相似的物质。通过将同一案例/样品的ATR-FTIR测试结果与独立的GC-MS或LC-MS结果进行比对，证实了直接ATR-FTIR测试的有效性。
