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25I-NBOH：在巴西吸墨纸癫痫发作中发现的一种新型强效血清素5-羟色胺受体激动剂。

25I-NBOH: a new potent serotonin 5-HT receptor agonist identified in blotter paper seizures in Brazil.

作者信息

Arantes Luciano Chaves, Júnior Ettore Ferrari, de Souza Luciano Figueiredo, Cardoso Andriele Costa, Alcântara Thaynara Lino Fernandes, Lião Luciano Morais, Machado Yuri, Lordeiro Rogério Araújo, Neto José Coelho, Andrade Ana Flávia B

机构信息

Instituto de Criminalística, Polícia Civil Do Distrito Federal, SPO, Lote 23, Bloco E, Brasília, DF 70610-200 Brazil.

Instituto de Criminalística Leonardo Rodrigues, Superintendência da Polícia Técnico-Científica do Estado de Goiás, Goiânia, GO 74425-030 Brazil.

出版信息

Forensic Toxicol. 2017;35(2):408-414. doi: 10.1007/s11419-017-0357-x. Epub 2017 Feb 16.

DOI:10.1007/s11419-017-0357-x
PMID:28706567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5486617/
Abstract

A new potent serotonin 5-HT receptor agonist was identified in blotter papers by several state level forensic laboratories in Brazil. The 25I-NBOH is a labile molecule, which fragments into 2C-I when analyzed by routine seized material screening gas chromatography (GC) methods. GC-mass spectrometry (MS), liquid chromatography-quadrupole time-of-flight-MS, and Fourier transform infrared and nuclear magnetic resonance analyses were performed to complete molecular characterization. Individual doses range from 300 to 1000 μg. Despite its being a potent 5-HT receptor agonist, 25I-NBOH is neither registered in the United Nations Office on Drugs and Crime (UNODC) nor classified as a scheduled substance in most countries. Sweden and Brazil seem to be the only countries to control 25I-NBOH. To our knowledge, this is the first scientific report dealing with identification of 25I-NBOH in actual seizures.

摘要

巴西的几个州级法医实验室在吸水纸上发现了一种新的强效血清素5-HT受体激动剂。25I-NBOH是一种不稳定的分子，在用常规查获材料筛选气相色谱（GC）方法分析时会分解为2C-I。进行了气相色谱-质谱（MS）、液相色谱-四极杆飞行时间质谱、傅里叶变换红外光谱和核磁共振分析以完成分子表征。个体剂量范围为300至1000μg。尽管25I-NBOH是一种强效5-HT受体激动剂，但它既未在联合国毒品和犯罪问题办公室（UNODC）登记，在大多数国家也未被列为管制物质。瑞典和巴西似乎是仅有的管控25I-NBOH的国家。据我们所知，这是第一份关于在实际查获物中鉴定出25I-NBOH的科学报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/2d32f9803240/11419_2017_357_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/682fa8a3b202/11419_2017_357_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/68c6cf0bfc05/11419_2017_357_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/b181bddc8d78/11419_2017_357_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/0376f14445fd/11419_2017_357_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/c682e56c8435/11419_2017_357_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/45a96c583642/11419_2017_357_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/2d32f9803240/11419_2017_357_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/682fa8a3b202/11419_2017_357_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/68c6cf0bfc05/11419_2017_357_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/b181bddc8d78/11419_2017_357_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/0376f14445fd/11419_2017_357_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/c682e56c8435/11419_2017_357_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/45a96c583642/11419_2017_357_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16fb/5486617/2d32f9803240/11419_2017_357_Fig7_HTML.jpg

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