拳参 A 和 B，来自决明子树皮的新型双色酮及其活性。
Fistulains A and B, New Bischromones from the Bark of Cassia fistula, and Their Activities.
机构信息
†Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, Yunnan, People's Republic of China.
‡Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, Yunnan, People's Republic of China.
出版信息
Org Lett. 2015 Jun 5;17(11):2638-41. doi: 10.1021/acs.orglett.5b01007. Epub 2015 May 12.
Fistulains A and B (1 and 2), two novel bischromones with unique coupling patterns, alone with their biosynthetic related compound 3, were isolated from the bark of Cassia fistula. Fistulain A represents a new type of dimeric chromone alkaloid biogenetically derived from a chromone and a tricyclic alkaloid through an unusual C-14-N linkage. Fistulain B has a new carbon skeleton with a C-14-C-5' linkage formed between two different chromone units. Fistulain A displayed anti-TMV activity, and both 1 and 2 showed weak cytotoxicities.
拳参因 A 和 B（1 和 2），两种新型的双色酮，具有独特的偶联模式，与它们的生物合成相关的化合物 3 一起，从决明子的树皮中分离出来。拳参因 A 代表了一种新型的二聚体色酮生物碱，它是通过一种不寻常的 C-14-N 键，由色酮和三环生物碱衍生而来。拳参因 B 具有一个新的碳骨架，两个不同的色酮单元之间形成了 C-14-C-5'键。拳参因 A 表现出抗 TMV 活性，并且 1 和 2 都表现出较弱的细胞毒性。
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