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内生真菌Xylaria sp. hg1009的次生代谢产物

Secondary Metabolites from the Endophytic Fungus Xylaria sp. hg1009.

作者信息

Chen Rong, Tang Jian-Wei, Li Xing-Ren, Liu Miao, Ding Wen-Ping, Zhou Yuan-Fei, Wang Wei-Guang, Du Xue, Sun Han-Dong, Puno Pema-Tenzin

机构信息

School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2018 Apr;8(2):121-129. doi: 10.1007/s13659-018-0158-x. Epub 2018 Mar 20.

DOI:10.1007/s13659-018-0158-x
PMID:29556983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5913051/
Abstract

A detailed chemical investigation of the secondary metabolites produced by the endophytic fungus Xylaria sp. isolated from the stems of Isodon sculponeatus afforded six new compounds, xylariahgins A-F (1-6), two new natural products (7 and 8), along with two known compounds (9 and 10) (Fig. 1). The structures of all compounds were unambiguously established by analyzing their spectroscopic data or referring to pertinent literature. Compounds 1-8 were tested for their cytotoxic activity against five human tumor cell lines.

摘要

对从溪黄草茎中分离出的内生真菌炭角菌属（Xylaria sp.）产生的次生代谢产物进行了详细的化学研究，从中获得了6个新化合物，即炭角菌素A - F（1 - 6）、2个新天然产物（7和8），以及2个已知化合物（9和10）（图1）。所有化合物的结构均通过光谱数据分析或参考相关文献得以明确确定。对化合物1 - 8针对5种人类肿瘤细胞系进行了细胞毒性活性测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f522/5913051/ff4c4f9cb2ab/13659_2018_158_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f522/5913051/060c24b1b023/13659_2018_158_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f522/5913051/c95df4e5df80/13659_2018_158_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f522/5913051/ff4c4f9cb2ab/13659_2018_158_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f522/5913051/060c24b1b023/13659_2018_158_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f522/5913051/c95df4e5df80/13659_2018_158_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f522/5913051/ff4c4f9cb2ab/13659_2018_158_Fig3_HTML.jpg

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本文引用的文献

1
A new phthalide from the endophytic fungus Xylaria sp. GDG-102.一种从内生真菌炭角菌属Xylaria sp. GDG-102中分离得到的新型苯酞。
Nat Prod Res. 2018 Apr;32(7):755-760. doi: 10.1080/14786419.2017.1311892. Epub 2017 Apr 7.
2
Bioactive Constituents from the Termite Nest-Derived Medicinal Fungus Xylaria nigripes.来自白蚁巢衍生药用真菌黑柄炭角菌的生物活性成分。
J Nat Prod. 2017 Jan 27;80(1):38-44. doi: 10.1021/acs.jnatprod.6b00249. Epub 2017 Jan 5.
3
The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects.
近年来，木层孔菌目及其次生代谢产物的生物多样性研究进展。
J Antibiot (Tokyo). 2021 Jan;74(1):1-23. doi: 10.1038/s41429-020-00376-0. Epub 2020 Oct 23.
天然二萜类化合物异佛尔酮 A 抑制硫氧还蛋白-1 并触发强烈的 ROS 介导的抗肿瘤作用。
Cancer Res. 2017 Feb 15;77(4):926-936. doi: 10.1158/0008-5472.CAN-16-0987. Epub 2016 Dec 23.
4
Phomopchalasins A and B, Two Cytochalasans with Polycyclic-Fused Skeletons from the Endophytic Fungus Phomopsis sp. shj2.茎点霉甲素和乙素，从内生真菌拟茎点霉属shj2中分离得到的两种具有多环稠合骨架的细胞松弛素。
Org Lett. 2016 Mar 4;18(5):1108-11. doi: 10.1021/acs.orglett.6b00214. Epub 2016 Feb 16.
5
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J Nat Prod. 2016 Jan 22;79(1):149-55. doi: 10.1021/acs.jnatprod.5b00814. Epub 2015 Dec 18.
6
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Org Lett. 2015 Jun 5;17(11):2638-41. doi: 10.1021/acs.orglett.5b01007. Epub 2015 May 12.
7
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J Nat Prod. 2015 Apr 24;78(4):730-5. doi: 10.1021/np500897y. Epub 2015 Feb 23.
8
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J Agric Food Chem. 2014 Nov 12;62(45):10962-9. doi: 10.1021/jf503846z. Epub 2014 Nov 3.
9
Aspergillines A-E, highly oxygenated hexacyclic indole-tetrahydrofuran-tetramic acid derivatives from Aspergillus versicolor.杂色曲霉产生的曲霉菌素A-E，高度氧化的六环吲哚-四氢呋喃-四酰胺酸衍生物。
Org Lett. 2014 Oct 3;16(19):5016-9. doi: 10.1021/ol502307u. Epub 2014 Sep 16.
10
Total synthesis of cytotoxic metabolite ( ± )-desmethyldiaportinol from Ampelomyces sp.来自白粉寄生孢的细胞毒性代谢物（±）-去甲基双孢菌素的全合成
Nat Prod Res. 2014;28(3):185-90. doi: 10.1080/14786419.2013.866111. Epub 2013 Dec 4.