内生真菌Xylaria sp. hg1009的次生代谢产物
Secondary Metabolites from the Endophytic Fungus Xylaria sp. hg1009.
作者信息
Chen Rong, Tang Jian-Wei, Li Xing-Ren, Liu Miao, Ding Wen-Ping, Zhou Yuan-Fei, Wang Wei-Guang, Du Xue, Sun Han-Dong, Puno Pema-Tenzin
机构信息
School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
出版信息
Nat Prod Bioprospect. 2018 Apr;8(2):121-129. doi: 10.1007/s13659-018-0158-x. Epub 2018 Mar 20.
A detailed chemical investigation of the secondary metabolites produced by the endophytic fungus Xylaria sp. isolated from the stems of Isodon sculponeatus afforded six new compounds, xylariahgins A-F (1-6), two new natural products (7 and 8), along with two known compounds (9 and 10) (Fig. 1). The structures of all compounds were unambiguously established by analyzing their spectroscopic data or referring to pertinent literature. Compounds 1-8 were tested for their cytotoxic activity against five human tumor cell lines.
对从溪黄草茎中分离出的内生真菌炭角菌属（Xylaria sp.）产生的次生代谢产物进行了详细的化学研究，从中获得了6个新化合物，即炭角菌素A - F（1 - 6）、2个新天然产物（7和8），以及2个已知化合物（9和10）（图1）。所有化合物的结构均通过光谱数据分析或参考相关文献得以明确确定。对化合物1 - 8针对5种人类肿瘤细胞系进行了细胞毒性活性测试。
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