使用手性双（咪唑啉）-钯催化剂催化α-苯硫基乙腈与亚胺的对映选择性反应。
Catalytic Enantioselective Reaction of α-Phenylthioacetonitriles with Imines Using Chiral Bis(imidazoline)-Palladium Catalysts.
作者信息
Kondo Masaru, Kobayashi Natsumi, Hatanaka Tsubasa, Funahashi Yasuhiro, Nakamura Shuichi
机构信息
Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555 (Japan), Fax: (+81) 52-735-5245.
Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan).
出版信息
Chemistry. 2015 Jun 15;21(25):9066-70. doi: 10.1002/chem.201501351. Epub 2015 May 12.
The catalytic enantioselective reaction of α-phenylthioacetonitriles with imines has been developed. The reaction of various imines proceeds in good yields and diastereo- and enantioselectivities in the presence of chiral bis(imidazoline)-palladium catalysts. The obtained products can be converted into β-aminonitrile or β-aminoamide compounds without loss of enantiopurity.
已开发出α-苯硫基乙腈与亚胺的催化对映选择性反应。在 chiral bis(imidazoline)-钯催化剂存在下，各种亚胺的反应以良好的产率、非对映选择性和对映选择性进行。所得到的产物可以转化为β-氨基腈或β-氨基酰胺化合物，而不会损失对映体纯度。
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