使用双（咪唑啉）-钯催化剂对二氯乙腈进行直接催化对映选择性曼尼希型反应。
Direct catalytic enantioselective Mannich-type reaction of dichloroacetonitrile using bis(imidazoline)-Pd catalysts.
作者信息
Kondo Masaru, Sugimoto Mami, Nakamura Shuichi
机构信息
Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
出版信息
Chem Commun (Camb). 2016 Nov 15;52(93):13604-13607. doi: 10.1039/c6cc07982b.
PMID:27808296
Abstract
The catalytic enantioselective Mannich-type reaction of dichloroacetonitrile with imines has been developed. Good yields and enantioselectivity were observed for the reaction with various imines using chiral bis(imidazoline) catalysts. β-Aminonitriles or β-aminoamide were obtained from products without the loss of enantiopurity.
摘要
二氯乙腈与亚胺的催化对映选择性曼尼希型反应已被开发出来。使用手性双（咪唑啉）催化剂与各种亚胺反应时，观察到了良好的产率和对映选择性。从产物中获得了β-氨基腈或β-氨基酰胺，且对映体纯度没有损失。
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