手性双（咪唑啉）钯（II）钳形配合物催化烯丙基腈与亚胺的对映选择性反应。
Catalytic Enantioselective Reaction of Allenylnitriles with Imines Using Chiral Bis(imidazoline)s Palladium(II) Pincer Complexes.
机构信息
Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, 466-8555, Japan.
Frontier Research Institute for Material Science, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, 466-8555, Japan.
出版信息
Angew Chem Int Ed Engl. 2017 Jul 17;56(30):8677-8680. doi: 10.1002/anie.201702429. Epub 2017 Jun 19.
The first highly enantioselective reaction of allenylnitriles with imines has been developed. Excellent yields and enantioselectivities were observed for the reaction with various imines using chiral Phebim-Pd complexes. This process offers a simple and efficient synthetic route for various functionalized α-vinylidene-β-aminonitriles and their derivatives.
已开发出首例对烯丙基腈与亚胺的高对映选择性反应。使用手性 Phebim-Pd 配合物，该反应与各种亚胺反应具有优异的产率和对映选择性。该过程为各种官能化的 α-亚乙烯基-β-氨腈及其衍生物提供了一种简单有效的合成途径。
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