†Department of Chemistry, The University of Memphis, Memphis, Tennessee 38152, United States.
§Department of Physics, The University of Memphis, Memphis, Tennessee 38152, United States.
ACS Appl Mater Interfaces. 2015 Jun 3;7(21):11637-47. doi: 10.1021/acsami.5b02741. Epub 2015 May 20.
We present the synthesis and application of a new type of dual magnetic and plasmonic nanostructures for magnetic-field-guided drug delivery and combined photothermal and photodynamic cancer therapy. Near-infrared-absorbing gold nanopopcorns containing a self-assembled iron oxide cluster core were prepared via a seed-mediated growth method. The hybrid nanostructures are superparamagnetic and show great photothermal conversion efficiency (η=61%) under near-infrared irradiation. Compact and stable nanocomplexes for photothermal-photodynamic therapy were formed by coating the nanoparticles with near-infrared-absorbing photosensitizer silicon 2,3-naphthalocyannie dihydroxide and stabilization with poly(ethylene glycol) linked with 11-mercaptoundecanoic acid. The nanocomplex showed enhanced release and cellular uptake of the photosensitizer with the use of a gradient magnetic field. In vitro studies using two different cell lines showed that the dual mode photothermal and photodynamic therapy with the assistance of magnetic-field-guided drug delivery dramatically improved the therapeutic efficacy of cancer cells as compared to the combination treatment without using a magnetic field and the two treatments alone. The "three-in-one" nanocomplex has the potential to carry therapeutic agents deep into a tumor through magnetic manipulation and to completely eradicate tumors by subsequent photothermal and photodynamic therapies without systemic toxicity.
我们提出了一种新型的双磁-等离子体纳米结构的合成与应用，用于磁场引导的药物输送以及光热和光动力联合癌症治疗。通过种子介导生长法制备了具有自组装氧化铁团簇核的近红外吸收金纳米爆米花。在近红外照射下，该混合纳米结构具有超顺磁性和优异的光热转换效率（η=61%）。通过用近红外吸收光敏剂硅 2,3-萘二羧酸二氢酯涂覆纳米粒子，并与通过 11-巯基十一酸连接的聚乙二醇稳定化，形成用于光热-光动力治疗的紧凑且稳定的纳米复合物。在使用梯度磁场的情况下，纳米复合物显示出光敏剂的增强释放和细胞摄取。使用两种不同的细胞系进行的体外研究表明，与不使用磁场的联合治疗以及单独两种治疗相比，磁场引导药物输送的双模式光热和光动力治疗极大地提高了癌细胞的治疗效果。这种“三位一体”的纳米复合物具有通过磁操作将治疗剂深入肿瘤内部并通过随后的光热和光动力治疗完全消除肿瘤而无全身毒性的潜力。
