Zheng H, Li Y, Xie N, Huang J L, Xu H F, Luo M
Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
Heart Failure Department, Shanghai East Hospital Affiliated to Tongji University, Shanghai, China.
Genet Mol Res. 2015 Apr 22;14(2):3775-83. doi: 10.4238/2015.April.22.6.
The soluble receptor for advanced glycation end-products (sRAGE) shows a close relationship with atherosclerosis. The goal of this study was to compare the levels of sRAGE in patients with and without aortic valve calcification and to investigate the relationship between them. After transthoracic echocardiographic examination, 120 male patients with aortic valve calcification and 120 age-matched male controls without aortic valve calcification were included in our study. sRAGE levels were compared between groups. The prevalence of diabetes mellitus and coronary artery disease were significantly higher in the aortic valve calcification group than in the control group (63.3 versus 45%, P = 0.01, and 65 versus 51.7%, P < 0.01, respectively). The levels of sRAGE were lower in the aortic valve calcification group than in the control group (203.8 ± 34.6 versus 324.7 ± 41.6 pg/mL, P < 0.01). In multivariate analysis, age, coronary artery disease, and sRAGE levels were independent predictors of aortic valve calcification. Our study demonstrates that sRAGE, which was proven to be a potential marker of atherosclerosis, might have a role in the development of aortic valve calcification.
晚期糖基化终末产物可溶性受体（sRAGE）与动脉粥样硬化关系密切。本研究旨在比较有和没有主动脉瓣钙化的患者的sRAGE水平，并探讨两者之间的关系。经胸超声心动图检查后，120例有主动脉瓣钙化的男性患者和120例年龄匹配的无主动脉瓣钙化的男性对照纳入我们的研究。比较两组之间的sRAGE水平。主动脉瓣钙化组糖尿病和冠状动脉疾病的患病率显著高于对照组（分别为63.3%对45%，P = 0.01；65%对51.7%，P < 0.01）。主动脉瓣钙化组的sRAGE水平低于对照组（203.8±34.6对324.7±41.6 pg/mL，P < 0.01）。多因素分析显示，年龄、冠状动脉疾病和sRAGE水平是主动脉瓣钙化的独立预测因素。我们的研究表明，sRAGE已被证明是动脉粥样硬化的潜在标志物，可能在主动脉瓣钙化的发生发展中起作用。
