Förthmann Benjamin, Aletta John M, Lee Yu-Wei, Terranova Chris, Birkaya Barbara, Stachowiak Ewa K, Stachowiak Michal K, Claus Peter
Hannover Medical School, Department of Neuroanatomy, Hannover, Germany.
CH3 BioSystems LLC, New York State Center for Bioinformatics & Life Sciences, Buffalo, New York, USA.
J Cell Physiol. 2015 Dec;230(12):2875-80. doi: 10.1002/jcp.25036.
A universal signaling module has been described which utilizes the nuclear form of Fibroblast growth Factor Receptor 1 (FGFR1) in a central role directing the post-mitotic development of neural cells through coordinated gene expression. In this review, we discuss in detail the current knowledge of FGFR1 nuclear interaction partners in three scenarios: (i) Engagement of FGFR1 in neuronal stem cells and regulation of neuronal differentiation; (ii) interaction with the orphan receptor Nurr1 in development of mesencephalic dopaminergic neurons; (iii) modulation of nuclear FGFR1 interactions downstream of nerve growth factor (NGF) signaling. These coalitions demonstrate the versatility of non-canonical, nuclear tyrosine kinase signaling in diverse cellular differentiation programs of neurons.
一种通用信号模块已被描述，其利用成纤维细胞生长因子受体1（FGFR1）的核形式发挥核心作用，通过协调基因表达来指导神经细胞的有丝分裂后发育。在本综述中，我们详细讨论了在三种情况下FGFR1核相互作用伙伴的当前知识：（i）FGFR1在神经元干细胞中的参与及神经元分化的调节；（ii）在中脑多巴胺能神经元发育过程中与孤儿受体Nurr1的相互作用；（iii）神经生长因子（NGF）信号下游核FGFR1相互作用的调节。这些联合作用证明了非经典核酪氨酸激酶信号在神经元不同细胞分化程序中的多功能性。
