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[神经安定镇痛、手术创伤与免疫]

[Neuroleptanalgesia, surgical trauma and immunity].

作者信息

Gadalov V P, Shakhtarin V V, Kuz'mina E G, Khachirov D G

出版信息

Anesteziol Reanimatol. 1989 Sep-Oct(5):21-3.

PMID:2596710
Abstract

Immune status and hormonal homeostasis have been studied in 26 patients with larynx cancer operated on (laryngectomy, extended laryngectomy) under neuroleptanalgesia. It has been established that 3 and 7 days after the operation there was a decrease in plasma cortisol level and an increase in B- and T-lymphocyte count and theophylline-resistant T-lymphocyte count in the peripheral blood. In 4 patients with postoperative complications (pharyngeal fistulas) there was a reverse correlation between cortisol content and B-lymphocyte count and T-lymphocyte blast transformation.

摘要

对26例接受喉癌手术(喉切除术、扩大喉切除术)的患者在神经安定镇痛下的免疫状态和激素稳态进行了研究。已确定术后3天和7天,血浆皮质醇水平降低,外周血中B淋巴细胞和T淋巴细胞计数以及茶碱抵抗性T淋巴细胞计数增加。在4例有术后并发症(咽瘘)的患者中,皮质醇含量与B淋巴细胞计数和T淋巴细胞母细胞转化之间存在负相关。

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