Alon E, Schulthess G, Axhausen C, Hossli G
Anaesthesist. 1981 Dec;30(12):623-6.
Analgesic effects as well as side effects, circulatory and respiratory parameters of 50 mg tramadol (Tramal) were compared with 0.3 mg buprenorphine (Temgesic) in a doubleblind, randomized study for the relief of postoperative pain. Buprenorphine produced a more potent and longer acting analgesic effect compared to tramadol, although slightly delayed. There were only few and slight side effects and no influence on the circulation and respiration. In the search for a new long-acting and strong analgesic Tramadol proved to be unable to replace buprenorphine in the control of postoperative pain.
在一项双盲、随机研究中，对50毫克曲马多（曲马朵）和0.3毫克丁丙诺啡（替利定）缓解术后疼痛的镇痛效果、副作用、循环和呼吸参数进行了比较。与曲马多相比，丁丙诺啡产生了更强效、作用更持久的镇痛效果，尽管起效稍延迟。副作用很少且轻微，对循环和呼吸无影响。在寻找一种新型长效强效镇痛药的过程中，事实证明曲马多在控制术后疼痛方面无法替代丁丙诺啡。
