简短报告：旧金山新诊断出感染艾滋病毒的人群中经常观察到近期感染、性传播感染及传播集群情况。
Brief Report: Recent Infection, Sexually Transmitted Infections, and Transmission Clusters Frequently Observed Among Persons Newly Diagnosed With HIV in San Francisco.
作者信息
Truong Hong-Ha M, Pipkin Sharon, OʼKeefe Kara J, Louie Brian, Liegler Teri, McFarland Willi, Grant Robert M, Bernstein Kyle, Scheer Susan
机构信息
*Department of Medicine, University of California, San Francisco, San Francisco, CA; †Gladstone Institute of Virology and Immunology, San Francisco, CA; ‡Department of Public Health, San Francisco, CA; and §San Francisco AIDS Foundation, San Francisco, CA.
出版信息
J Acquir Immune Defic Syndr. 2015 Aug 15;69(5):606-9. doi: 10.1097/QAI.0000000000000681.
Abstract
There were 1311 newly diagnosed HIV cases in San Francisco between 2005 and 2011 that were linked to care at publicly funded facilities and had viral sequences available for analysis. Of the 214 cases characterized as recently infected with HIV at the time of diagnosis, 25% had a recent sexually transmitted infection diagnosis (vs. 10% among longer-standing HIV infections, P < 0.001) and 57% were part of a phylogenetic transmission cluster (vs. 42% among longer-standing HIV infection, P < 0.001). The association observed between recent HIV infection and having a sexually transmitted infection diagnosis during the interval overlapping likely HIV acquisition points to potential opportunities to interrupt HIV transmission.
摘要
2005年至2011年间，旧金山有1311例新诊断的HIV病例，这些病例与公共资助机构的护理相关联，并且有病毒序列可供分析。在诊断时被确定为近期感染HIV的214例病例中，25%近期有性传播感染诊断（而在长期感染HIV的病例中这一比例为10%，P<0.001），57%属于系统发育传播簇（而在长期感染HIV的病例中这一比例为42%，P<0.001）。在可能感染HIV的重叠时间段内，近期HIV感染与有性传播感染诊断之间的关联表明存在中断HIV传播的潜在机会。
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