Altınbaş Gülçin, Altınbaş Kürşat, Gülöksüz Selin Aktan, Gülöksüz Sinan, Aydemir Ömer, Özgen Güliz
Psychiatry Unit, Private Barbaros Clinic, Canakkale, Turkey.
Department of Psychiatry, School of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Compr Psychiatry. 2015 Jul;60:73-7. doi: 10.1016/j.comppsych.2015.03.008. Epub 2015 Apr 2.
Panic disorder is one of the highly heritable anxiety disorders; and temperament characteristics are considered predicting liability to panic disorder. Accumulating evidence suggests temperament characteristics are intermediate phenotypes for clinical conditions. Given this background, we aimed to investigate temperament characteristics in patients with panic disorder, their first-degree relatives, and healthy controls.
Study sample consisted of 60 patients with panic disorder, 37 first-degree relatives of these patients, and 37 age, gender, and education level matched healthy controls (HC). SCID-I, the Panic Agoraphobia Scale, and the State and Trait Anxiety Inventory were applied to assess clinical characteristics of the patient group. Temperament characteristics were assessed using the Temperament Evaluation of Memphis, Pisa, Paris, San Diego Autoquestionnaire (TEMPS-A).
Anxious, depressive, cyclothymic, and irritable temperament scores of patients were higher than those of HC. There was no difference between the patients and the relatives, with the exception of higher anxious temperament scores in patients.
Overall, our findings suggest that anxious temperament characteristic might be a trait marker for liability to panic disorder. Further research with a prospective design in a larger sample is required to confirm our findings.
惊恐障碍是遗传性较高的焦虑症之一；气质特征被认为是预测惊恐障碍易感性的因素。越来越多的证据表明，气质特征是临床疾病的中间表型。基于此背景，我们旨在研究惊恐障碍患者、其一级亲属和健康对照者的气质特征。
研究样本包括60例惊恐障碍患者、这些患者的37名一级亲属以及37名年龄、性别和教育水平相匹配的健康对照者（HC）。应用SCID-I、惊恐广场恐怖量表以及状态-特质焦虑量表来评估患者组的临床特征。使用孟菲斯、比萨、巴黎、圣地亚哥自动问卷气质评估量表（TEMPS-A）来评估气质特征。
患者的焦虑、抑郁、环性心境和易怒气质得分高于健康对照者。患者与亲属之间无差异，但患者的焦虑气质得分较高。
总体而言，我们的研究结果表明，焦虑气质特征可能是惊恐障碍易感性的一个特质标记。需要在更大样本中进行前瞻性设计的进一步研究来证实我们的发现。
