Abinader E G, Sharif D, Sagiv M, Goldhammer E
Heart Institute, Haifa Medical Center (Rothschild), Faculty of Medicine, Technion-Israel Institute.
Angiology. 1989 Dec;40(12):1052-7. doi: 10.1177/000331978904001206.
Doppler interrogation at the in-flow of the left ventricle was used to test the effects of isometric stress on ventricular filling in 7 hypertensive subjects with mild to moderate left ventricular hypertrophy, aged forty-two +/- seven years, compared with 9 matched healthy control males. In the hypertensive patients at rest, peak early diastolic (E) velocity was lower, and atrial (A) velocity higher, with lower E/A peak velocity ratios than in normals (p less than 0.05). These differences were more accentuated during isometric stress. Atrial filling fractions were higher in hypertensives (37 +/- 6%) than in normals (24 +/- 7%) at rest, p less than 0.05, and this difference increased during isometric stress (44 +/- 9% versus 30 +/- 11%). Thus, isometric stress accentuated the reliance of left ventricular filling on atrial contribution and may be applied for the detection of early ventricular filling abnormalities in patients with mild hypertension. The systolic blood pressure and the hypertrophic process were both important determinants of left ventricular diastolic filling.
对7名年龄在42±7岁、患有轻度至中度左心室肥厚的高血压患者，与9名相匹配的健康对照男性，采用左心室流入道多普勒检查来测试等长应激对心室充盈的影响。在静息状态下，高血压患者的舒张早期峰值（E）速度较低，心房（A）速度较高，E/A峰值速度比低于正常人（p<0.05）。这些差异在等长应激期间更为明显。静息时，高血压患者的心房充盈分数（37±6%）高于正常人（24±7%），p<0.05，且这种差异在等长应激期间增大（44±9% 与 30±11%）。因此，等长应激加剧了左心室充盈对心房贡献的依赖，可用于检测轻度高血压患者的早期心室充盈异常。收缩压和肥厚过程都是左心室舒张期充盈的重要决定因素。
