Takata Y, Takishita S, Koga T, Nakao Y, Okamura K, Yao T, Takemura K, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Angiology. 1989 Dec;40(12):1079-82. doi: 10.1177/000331978904001210.
Nifedipine was administered orally to 2 patients with primary hyperparathyroidism before and after parathyroidectomy. The operation lowered serum calcium concentration and parathyroid hormone but did not alter plasma renin activity, plasma aldosterone concentration, and serum magnesium. The hypotensive effects of nifedipine were markedly enhanced with the decrease in serum calcium concentration following parathyroidectomy. Thus, the level of serum calcium concentration may modulate the hypotensive effect of nifedipine in humans.
对2例原发性甲状旁腺功能亢进患者在甲状旁腺切除术前和术后口服硝苯地平。手术降低了血清钙浓度和甲状旁腺激素，但未改变血浆肾素活性、血浆醛固酮浓度和血清镁。甲状旁腺切除术后，随着血清钙浓度的降低，硝苯地平的降压作用明显增强。因此，血清钙浓度水平可能调节硝苯地平在人体内的降压作用。
