Xu Rui-Xia, Wu Na-Qiong, Li Sha, Zhang Yan, Li Xiao-Lin, Guo Yuan-Lin, Zhu Cheng-Gang, Liu Geng, Dong Qian, Li Jian-Jun
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Chin J Integr Med. 2016 Sep;22(9):660-5. doi: 10.1007/s11655-015-2140-3. Epub 2015 May 13.
To investigate the effects of Hedan Tablet () on serum lipid profile, proprotein convertase subtilisin/kexin type 9 (PSCK9) and high-density lipoprotein (HDL) subfractions in patients with hyperlipidemia.
Thirty-seven patients with hyperlipidemia were randomized to treatment with Hedan Tablet 4.38 g/day as Hedan group (18 cases) or placebo (19 cases) as control group for 8 weeks. The lipid profile, PCSK9 and HDL subfractions were determined at day 0 and week 8 in both groups respectively.
Hedan treatment for 8 weeks mildly decreased serum low-density lipoprotein cholesterol (LDL-C) levels, while no changes were found in total cholesterol (TC), triglycerides (TG) and PCSK9 concentrations. Furthermore, Hedan treatment increased the concentration of large high-density lipoprotein cholesterol (HDL-C) and the percentage of large HDL subfraction, while decreased the concentration of small HDL-C and the percentage of small HDL subfraction without changing serum HDL-C levels in patients with hyperlipidemia.
Hedan treatment of 4.38 g per day for 8 weeks could confer a favorable effects on serum LDL-C concentration as well as HDL subfractions.
探讨和丹片对高脂血症患者血脂谱、前蛋白转化酶枯草溶菌素9型（PCSK9）及高密度脂蛋白（HDL）亚组分的影响。
将37例高脂血症患者随机分为两组，和丹组18例，给予和丹片4.38 g/d治疗；对照组19例，给予安慰剂治疗，疗程均为8周。分别于第0天和第8周测定两组患者的血脂谱、PCSK9及HDL亚组分。
和丹片治疗8周后可轻度降低血清低密度脂蛋白胆固醇（LDL-C）水平，而总胆固醇（TC）、甘油三酯（TG）及PCSK9浓度无变化。此外，和丹片治疗可升高高脂血症患者大颗粒高密度脂蛋白胆固醇（HDL-C）浓度及大颗粒HDL亚组分百分比，降低小颗粒HDL-C浓度及小颗粒HDL亚组分百分比，而血清HDL-C水平无变化。
每天服用4.38 g和丹片治疗8周可对血清LDL-C浓度及HDL亚组分产生有益影响。
