Li J-H, Han L, Du T-P, Guo M-J
Department of General Surgery, Xinxiang Central Hospital, Xinxiang, Henan, China.
Eur Rev Med Pharmacol Sci. 2015 Apr;19(8):1345-50.
The aim of this study is to investigate the effect of low-nitrogen and low-calorie parenteral nutrition (PN) combined with enteral nutrition (EN) on the inflammatory cytokines and immune function in patients with gastric cancer.
Between May 2012 and May 2014, 90 patients undergoing surgery for gastric cancer in our institution were involved in this double blind placebo study and randomly divided into experimental group and control group, 45 patients of each group. Patients in the control group would receive total parenteral nutrition (TPN) whereas patients in the experimental group would be supported with low-nitrogen and low-calorie PN combined with EN.
On the 7th postoperative day 7, levels of IgA, IgM and IgG in experimental group were significantly higher than those in the control group and preoperative values (p < 0.05). CRP level was significantly lower than that of controls and preoperatively (p < 0.05). Levels of IL-2 and TNF-α were significantly higher than those of controls and preoperatively (p < 0.05).
As low-nitrogen and low-calorie PN combined with EN can effectively improve the immune function, reduce the inflammatory reactions and improve the postoperative quality of life (QoL) and prognosis in patients with gastric cancer, it is suitable for clinical application.
本研究旨在探讨低氮低热量肠外营养（PN）联合肠内营养（EN）对胃癌患者炎症细胞因子及免疫功能的影响。
2012年5月至2014年5月期间，我院90例行胃癌手术的患者参与了这项双盲安慰剂研究，并随机分为实验组和对照组，每组45例。对照组患者接受全肠外营养（TPN），而实验组患者则采用低氮低热量PN联合EN支持。
术后第7天，实验组IgA、IgM和IgG水平显著高于对照组及术前水平（p<0.05）。CRP水平显著低于对照组及术前水平（p<0.05）。IL-2和TNF-α水平显著高于对照组及术前水平（p<0.05）。
低氮低热量PN联合EN可有效改善胃癌患者的免疫功能，减轻炎症反应，提高术后生活质量（QoL）及预后，适合临床应用。
