Xiao Xue, Mi Yan-Ni, Wang Fa, Zhang Bing-Hua, Cao Lei, Cao Yong-Xiao
Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Shaanxi Institute for Food and Drug Control, Xi'an, Shaanxi, 710061, China.
Biomed Chromatogr. 2015 Dec;29(12):1849-58. doi: 10.1002/bmc.3506. Epub 2015 Jun 2.
This study investigated vitamin K1 (VK1 ) distribution following intravenous vitamin K1-fat emulsion (VK1 -FE) administration and compared it with that after VK1 injection. Rats were intravenously injected with VK1-FE or VK1 . The organ and tissue VK1 concentrations were determined using high-performance liquid chromatography method at 0.5, 2 and 4 h to determine distribution, equilibrium and elimination phases, respectively. In the VK1-FE group, the plasma, heart and spleen VK1 concentrations decreased over time. However, other organs like liver, lung, kidney, muscle and testis, reached peak VK1 concentrations at 2 h. In the VK1 injection group, the liver VK1 concentrations were significantly higher than those in other organs at the three time points. However, VK1 concentrations in the other organs peaked at 2 h. In addition, in VK1-FE group, the heart, spleen and lung VK1 concentrations were significantly higher than those in the VK1 injection group at the three time points, and the liver VK1 concentration was significantly higher than that in the VK1 injection group at 4 h. The VK1 amount was greatest in the liver compared with the other organs. Thus, the liver is the primary organ for VK1 distribution. The distribution of VK1 is more rapid when injected as VK1-FE than as VK1 .
本研究调查了静脉注射维生素K1脂肪乳剂（VK1-FE）后维生素K1（VK1）的分布情况，并将其与注射VK1后的情况进行比较。给大鼠静脉注射VK1-FE或VK1。分别在0.5、2和4小时使用高效液相色谱法测定器官和组织中的VK1浓度，以确定分布、平衡和消除阶段。在VK1-FE组中，血浆、心脏和脾脏中的VK1浓度随时间下降。然而，肝脏、肺、肾脏、肌肉和睾丸等其他器官在2小时时达到VK1浓度峰值。在VK1注射组中，在三个时间点肝脏中的VK1浓度均显著高于其他器官。然而，其他器官中的VK1浓度在2小时时达到峰值。此外，在VK1-FE组中，在三个时间点心脏、脾脏和肺中的VK1浓度均显著高于VK1注射组，且在4小时时肝脏中的VK1浓度显著高于VK1注射组。与其他器官相比，肝脏中的VK1含量最高。因此，肝脏是VK1分布的主要器官。以VK1-FE形式注射时VK1的分布比以VK1形式注射时更快。
