Lalji Ulrich C, Wildberger Joachim E, Zur Hausen Axel, Bendek Matyas, Dingemans Anne-Marie C, Hochstenbag Monique, Das Marco
Department of Radiology, Maastricht University Medical Center, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
GROW School of Oncology and Developmental Biology, Maastricht University Medical Center, P. Debyelaan 25, PO Box 5800, 6202 Z, Maastricht, The Netherlands.
Cardiovasc Intervent Radiol. 2015 Dec;38(6):1603-10. doi: 10.1007/s00270-015-1098-z. Epub 2015 May 13.
Using large-core biopsy needles in CT-guided percutaneous transthoracic needle biopsies (PTNB) may be advantageous in terms of larger specimens, which facilitate more extensive histopathological, immunohistochemical, and molecular examination of tumor tissue. The aim of this study was to evaluate the success rate and safety in CT-guided PTNB using 10G large-core biopsy needles.
35 patients with intrathoracic lesions suspected of malignancy underwent CT-guided PTNB using dedicated large-core biopsy needles (10G Spirotome™, Medinvents, Hasselt, Belgium). Location, tumor size, number of pleural passes, number of biopsies, histologic result, and complications (pneumothorax, bleeding) were recorded.
Lesion location varied from pleural to hilar location. Mean tumor size was 3.5 cm (range 0.7-9.2 cm). Only one pleural passage was necessary in all patients. Mean distance from the pleura to the lesion was 2.6 cm (max 9.2 cm). Large-core biopsy (10G) was successful in 88.6%. Pneumothorax was found in 40%. Minor intraparenchymal bleeding was present in 14 patients. No major complications were recorded.
Large-core biopsy with 10G did not show higher complication rates compared to literature. It is technically feasible and safe. The obtained larger specimens may especially be helpful for the increasing demands of extensive molecular analysis for stratified patient care.
在CT引导下经皮经胸针吸活检（PTNB）中使用大芯活检针，就获取更大的标本而言可能具有优势，这有助于对肿瘤组织进行更广泛的组织病理学、免疫组织化学和分子检查。本研究的目的是评估使用10G大芯活检针进行CT引导下PTNB的成功率和安全性。
35例怀疑为恶性的胸内病变患者接受了使用专用大芯活检针（10G Spirotome™，Medinvents，哈瑟尔特，比利时）的CT引导下PTNB。记录病变位置、肿瘤大小、胸膜穿刺次数、活检次数、组织学结果和并发症（气胸、出血）。
病变位置从胸膜到肺门不等。平均肿瘤大小为3.5 cm（范围0.7 - 9.2 cm）。所有患者仅需一次胸膜穿刺。从胸膜到病变的平均距离为2.6 cm（最大9.2 cm）。大芯活检（10G）成功率为88.6%。40%的患者发现气胸。14例患者存在轻微的实质内出血。未记录到严重并发症。
与文献报道相比，10G大芯活检并未显示出更高的并发症发生率。它在技术上是可行且安全的。所获得的更大标本对于分层患者护理中对广泛分子分析不断增长的需求可能特别有帮助。
