慢性中耳炎患者血清对氧磷酶和芳基酯酶活性
Serum paraoxonase and arylesterase activities in patients with chronic otitis media.
作者信息
Turan Mahfuz, Ucler Rıfkı, Aslan Mehmet, Kalkan Ferhat, Taskın Abdullah, Garca Mehmet Fatih, Cankaya Hakan
出版信息
Redox Rep. 2015;20(6):241-5. doi: 10.1179/1351000215Y.0000000012. Epub 2015 May 13.
OBJECTIVES
Paraoxonase-1 (PON1) prevents oxidative stress by inhibiting the oxidation of cell membrane lipids by the reactive oxygen species that form during acute and chronic inflammation. The aim of this study was to investigate serum PON1 activity and oxidative stress in patients with chronic otitis media (COM).
METHODS
Fifty consecutive patients with COM and 55 controls were enrolled in the present study. The patients were divided into two groups according to the presence of cholesteatoma. The serum PON1 arylesterase activities and lipid hydroperoxide (LOOH) levels were determined.
RESULTS
Serum paraoxonase and arylesterase activities were significantly lower in the COM patients than in the controls (P < 0.001 for all comparisons), whereas the LOOH levels were significantly higher (P < 0.001).
DISCUSSION
These results indicated that a lower level of PON1 activity was associated with an oxidant-antioxidant imbalance. In addition, decreased PON1 activity may play an important role in the pathophysiology of COM.
目的
对氧磷酶-1（PON1）通过抑制急性和慢性炎症期间形成的活性氧对细胞膜脂质的氧化来预防氧化应激。本研究旨在调查慢性中耳炎（COM）患者的血清PON1活性和氧化应激情况。
方法
本研究纳入了50例连续的COM患者和55例对照。根据胆脂瘤的存在情况将患者分为两组。测定血清PON1芳基酯酶活性和脂质过氧化氢（LOOH）水平。
结果
COM患者的血清对氧磷酶和芳基酯酶活性显著低于对照组（所有比较P<0.001），而LOOH水平显著更高（P<0.001）。
讨论
这些结果表明较低水平的PON1活性与氧化-抗氧化失衡有关。此外，PON1活性降低可能在COM的病理生理学中起重要作用。
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