Koc Sema, Kıyıcı Halil, Toker Aysun, Soyalıç Harun, Aslan Huseyin, Kesici Hakan, Karaca Zafer I
Antalya Education and Research Hospital, Department of ENT Head and Neck Surgery, Antalya, Turkey.
Mevlana University, School of Medicine, Department of Pathology, Konya, Turkey.
Braz J Otorhinolaryngol. 2017 Sep-Oct;83(5):541-545. doi: 10.1016/j.bjorl.2016.06.008. Epub 2016 Jul 20.
The ethiopathogenesis of tympanosclerosis has not been completely under- stood yet. Recent studies have shown that free oxygen radicals are important in the formation of tympanosclerosis. Melatonin and Vitamin C are known to be a powerful antioxidant, interacts directly with Reactive Oxygen Species and controls free radical-mediated tissue damage.
To demonstrate the possible preventative effects of melatonin and Vitamin C on tympanosclerosis in rats by using histopathology and determination of total antioxidant status total antioxidant status.
Standard myringotomy and standard injury were performed in the middle ear of 24 rats. The animals were divided into three groups: Group 1 received melatonin, Group 2 received vitamin C, and Group 3 received saline solution.
The mean values of total antioxidant status were similar in the all study groups before the treatment period. The mean values of total antioxidant status were significantly higher in the melatonin and vitamin C groups compared to control group but vitamin C with melatonin groups were similar after the treatment period (p<0.001). Minimum and maximum wall thicknesses were lower in the melatonin and vitamin C groups compared to the control group but the differences were insignificant.
Melatonin increases total antioxidant status level and might have some effect on tympanosclerosis that develops after myringotomy.
鼓室硬化症的发病机制尚未完全明确。近期研究表明，游离氧自由基在鼓室硬化症的形成过程中起重要作用。褪黑素和维生素C是已知的强效抗氧化剂，可直接与活性氧相互作用并控制自由基介导的组织损伤。
通过组织病理学和总抗氧化状态测定，证明褪黑素和维生素C对大鼠鼓室硬化症可能具有的预防作用。
对24只大鼠的中耳进行标准鼓膜切开术和标准损伤。将动物分为三组：第1组接受褪黑素，第2组接受维生素C，第3组接受生理盐水。
治疗期前，所有研究组的总抗氧化状态平均值相似。治疗期后，褪黑素组和维生素C组的总抗氧化状态平均值显著高于对照组，但维生素C与褪黑素联合组相似（p<0.001）。与对照组相比，褪黑素组和维生素C组的最小和最大壁厚较低，但差异不显著。
褪黑素可提高总抗氧化状态水平，可能对鼓膜切开术后发生的鼓室硬化症有一定作用。
