Deadmond Melissa A, Smith-Gagen Julie A
School of Community Health Sciences, University of Nevada, Mail Stop 274, 1664 North Virginia Street, Reno, NV, 89557, USA.
Biology Department, Truckee Meadows Community College, Mail Stop SIER 200S, 7000 Dandini Boulevard, Reno, NV, 89512, USA.
J Cancer Res Clin Oncol. 2015 Dec;141(12):2131-8. doi: 10.1007/s00432-015-1983-5. Epub 2015 May 13.
Recent diagnostic and cancer reporting changes influencing myeloproliferative neoplasms (MPNs) encourage the assessment of trends and examination of the recently identified MPN subtypes: polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), across the age continuum by race and ethnicity.
Surveillance, Epidemiology, and End Results data provided MPN incidence data since 1973 and MPN subtype data since 2001. Joinpoint regression estimated annual percent changes. Poisson regression estimated risk ratios.
The 2005 JAK2 V617F discovery and the 2008 WHO diagnostic guideline for the JAK2 V617F mutation coincide with a 31 % increase in ET and a 21 % decrease in PV incidence rates. We found that younger women had a 13-33 % higher ET risk and that women under the age of 34 had a 58 % higher PMF risk, relative to men. Blacks, aged 35-49 with a higher ET risk, also had a 69 % higher PMF risk relative to whites.
Demographic characteristic of ET and PMF patients may be useful for improving risk prediction and informing clinical screening and treatment strategies. Changing guidelines, new discoveries, and in-depth analysis of a large population-based study have implications for accurately identifying incident cases of MPNs, MPN subgroups, and health resource planning.
近期影响骨髓增殖性肿瘤（MPN）的诊断和癌症报告变化，促使我们评估不同年龄阶段、种族和族裔的MPN趋势，并对最近确定的MPN亚型：真性红细胞增多症（PV）、原发性血小板增多症（ET）和原发性骨髓纤维化（PMF）进行研究。
监测、流行病学和最终结果数据提供了自1973年以来的MPN发病率数据以及自2001年以来的MPN亚型数据。Joinpoint回归估计年度百分比变化。泊松回归估计风险比。
2005年JAK2 V617F的发现以及2008年世界卫生组织关于JAK2 V617F突变的诊断指南，与ET发病率增加31%和PV发病率下降21%相吻合。我们发现，年轻女性患ET的风险比男性高13%-33%，34岁以下女性患PMF的风险比男性高58%。35-49岁的黑人患ET的风险较高，患PMF的风险也比白人高69%。
ET和PMF患者的人口统计学特征可能有助于改善风险预测，并为临床筛查和治疗策略提供参考。指南的变化、新的发现以及对一项大型基于人群研究的深入分析，对于准确识别MPN的发病病例、MPN亚组以及卫生资源规划具有重要意义。
