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一种客观、快速且可重复的测量A型肉毒毒素有效性方法的初步报告

Preliminary Report on an Objective, Fast, and Reproducible Method to Measure the Effectiveness of Botulinum Toxin Type A.

作者信息

Cavallini Maurizio

机构信息

Dr Cavallini is a plastic surgeon in private practice in Milano, Italy.

出版信息

Aesthet Surg J. 2015 Aug;35(6):715-20. doi: 10.1093/asj/sju104. Epub 2015 May 12.

DOI:10.1093/asj/sju104
PMID:25969436
Abstract

BACKGROUND

The injection of botulinum toxin type A for cosmetic proposes is a popular procedure, although the interpretation of its effectiveness still poses a challenge. In fact, although the methods that evaluate the efficacy of the treatment are validated and reliable, they are usually based on subjective scales, while an objective and quantitative scale is still needed.

OBJECTIVES

I propose an objective, fast, and reproducible method to evaluate the severity of wrinkles with a three-dimensional imaging and texture analysis.

METHODS

Digital Analysis of the Cutaneous Surface (DACS) is employed to analyze cutaneous texture. Measures are performed in the glabellar area before and one month after infiltration of 15 units of onabotulinumtoxin-A.

RESULTS

Eight women were included in this study. DACS was able to detect improvements in all cases. On average, static lines decreased by 12.4% and dynamic lines by 41.2%.

CONCLUSIONS

DACS provides an objective, direct, fast, and reproducible method to measure the results of botulinum toxin type A usage. It avoids the use of subjective scores, gives a direct measure of the wrinkles, is simple to perform, and allows the operator to analyze only the desired area.

LEVEL OF EVIDENCE

4 Therapeutic.

摘要

背景

注射A型肉毒杆菌毒素用于美容是一种常见的操作,但其有效性的评估仍具有挑战性。事实上,尽管评估治疗效果的方法经过验证且可靠,但它们通常基于主观量表,而仍需要一种客观的定量量表。

目的

我提出一种通过三维成像和纹理分析来评估皱纹严重程度的客观、快速且可重复的方法。

方法

采用皮肤表面数字分析(DACS)来分析皮肤纹理。在眉间区域注射15单位的A型肉毒杆菌毒素前及注射后1个月进行测量。

结果

本研究纳入了8名女性。DACS能够在所有病例中检测到改善情况。静态纹平均减少了12.4%,动态纹减少了41.2%。

结论

DACS提供了一种客观、直接、快速且可重复的方法来测量A型肉毒杆菌毒素的使用效果。它避免了使用主观评分,能直接测量皱纹,操作简单,且允许操作人员仅分析所需区域。

证据水平

4级治疗性。

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