[卡马西平与盐酸曲米帕明的亚硝化产物N-亚硝基亚氨基芪和N-亚硝基亚氨基二苄基的微生物致突变性试验]
[Microbial mutagenicity testing of N-nitrosoiminostilbene and N-nitrosoiminodibenzyl, the nitrosation products of the drugs carbamazepine and trimipramine hydrochloride].
作者信息
Ziebarth D, Schramm T, Braun R
机构信息
Zentralinstitut für Krebsforschung der Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
出版信息
Arch Geschwulstforsch. 1989;59(6):393-7.
PMID:2596954
Abstract
The active agents of the drugs Finlepsin and Herphonal, carbamazepine and trimipramine, were nitrosated under simulated human gastric conditions. For both formed N-nitroso compounds, N-nitroso iminostilbene (N-nitroso-5H-dibenz(b,f)azepine) and N-nitroso iminodibenzyl (N-nitroso-10,11-dihydro-5H-dibenz(b,f)azepine), tests for mutagenic potency in the Ames-test gave negative results.
摘要
药物芬lepsin和赫普诺尔的活性成分卡马西平和三甲丙咪嗪在模拟人体胃部条件下被亚硝化。对于两种形成的N-亚硝基化合物，即N-亚硝基亚氨基芪（N-亚硝基-5H-二苯并[b,f]氮杂卓）和N-亚硝基亚氨基二苄（N-亚硝基-10,11-二氢-5H-二苯并[b,f]氮杂卓），艾姆斯试验中的致突变性测试给出了阴性结果。
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