Mangla Ankit, Hamad Hussein, Yadav Udit, Telfer Margaret
Department of Internal Medicine, Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, Ill., USA.
Division of Hematology and Oncology, Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, Ill., USA.
Case Rep Gastroenterol. 2015 Apr 17;9(1):93-100. doi: 10.1159/000381305. eCollection 2015 Jan-Apr.
Alcohol abuse is associated with both potentiating and antagonizing hemostatic states. Liver cirrhosis is an independent causal factor for many bleeding complications. The long-term effects of alcohol abuse coupled with advanced liver cirrhosis are additive in favor of bleeding. We report the case of a patient with a history of alcohol abuse who presented with liver cirrhosis and nontraumatic muscle hematoma diagnosed as a spontaneous hematoma of the gastrocnemius muscle. He was managed conservatively with infusions of fresh frozen plasma and platelets, which resulted in resolution of the hematoma. The pathogenesis of 'spontaneous' muscle hematoma remains anecdotal, but since it is reported in patients on anticoagulant therapy or with hemostatic disorders, it is hypothetically related to severely deranged coagulation. Here we review the relevant literature pertaining to the pathogenesis, presentation and treatment options available for treating this often fatal complication of bleeding diatheses.
酒精滥用与增强和拮抗止血状态均有关联。肝硬化是许多出血并发症的独立病因。酒精滥用与晚期肝硬化的长期影响叠加,更易导致出血。我们报告一例有酒精滥用史的患者,其患有肝硬化并出现非创伤性肌肉血肿,诊断为腓肠肌自发性血肿。通过输注新鲜冰冻血浆和血小板进行保守治疗,血肿得以消退。“自发性”肌肉血肿的发病机制仍缺乏充分证据,但鉴于其在接受抗凝治疗或患有止血障碍的患者中有所报道,推测其与严重紊乱的凝血功能有关。在此,我们回顾了有关该出血性素质常见致命并发症的发病机制、临床表现及治疗选择的相关文献。