Rizk Nasser M, El-Menyar Ayman, Egue Huda, Souleman Wais Idil, Mohamed Baluli Hissa, Alali Khalid, Farag Fathi, Younes Noura, Al Suwaidi Jassim
Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar.
Cardiology Unit, Ahmed Maher Teaching Hospital, Cairo, Egypt ; Clinical Medicine, Weill Cornell Medical School, P.O. Box 24144, Doha, Qatar.
Biomed Res Int. 2015;2015:678924. doi: 10.1155/2015/678924. Epub 2015 Mar 8.
Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS).
We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients. Genotyping of the rs599839, rs646776, and rs4970834 polymorphisms was performed on Arab patients undergoing coronary angiography for ACS. Patients were divided into group A (ACS with insignificant stenosis (<50%)) and group B (with significant stenosis (≥ 50%)).
Patients carrying the minor G allele in rs599839 had significantly lower mean of LDL-C (2.58 versus 3.44 mM, P = 0.026) than homozygous A allele carriers (GG versus AA). Carriers of minor C allele in rs64776 had significantly higher mean of HDL-C (2.16 versus 1.36 mM, P = 0.004) than carriers of the T alleles (AA versus GG). The odd ratio and 95% confidence interval for dominant model for G allele carriers of rs599839 were 0.51 (0.30-0.92), P = 0.038, among patients with significant stenosis.
Polymorphisms rs646776 and rs599839 of locus 1p13.3 were significantly associated with LDL-C and other lipid parameters. In addition, the G-allele carriers of variant rs599839 had a significant protective effect against the atherosclerosis.
位于1号染色体1p13.3位点的几种多态性对低密度脂蛋白胆固醇（LDL-C）、动脉粥样硬化和急性冠状动脉综合征（ACS）有显著影响。
我们旨在研究1p13.3位点的rs599839、rs646776和rs4970834与ACS患者血清LDL-C及冠状动脉狭窄严重程度之间的关联。对因ACS接受冠状动脉造影的阿拉伯患者进行rs599839、rs646776和rs4970834多态性的基因分型。患者分为A组（狭窄程度不显著（<50%）的ACS）和B组（狭窄程度显著（≥50%）的ACS）。
rs599839中携带次要G等位基因的患者的LDL-C均值（2.58对3.44 mM，P = 0.026）显著低于纯合A等位基因携带者（GG对AA）。rs64776中次要C等位基因携带者的HDL-C均值（2.16对1.36 mM，P = 0.004）显著高于T等位基因携带者（AA对GG）。在狭窄程度显著的患者中，rs599839的G等位基因携带者显性模型的比值比和95%置信区间为0.51（0.30 - 0.92），P = 0.038。
1p13.3位点的多态性rs646776和rs599839与LDL-C及其他血脂参数显著相关。此外，rs599839变异的G等位基因携带者对动脉粥样硬化有显著的保护作用。
