Department of Medical Genetics Faculty of Medicine Umm Al-Qura University, Makkah, Saudi Arabia.
Science and Technology Unit Umm Al Qura University, Makkah, Saudi Arabia.
Dis Markers. 2024 Aug 7;2024:8278727. doi: 10.1155/2024/8278727. eCollection 2024.
Coronary artery diseases may be affected by several genetic and nongenetic factors. Single-nucleotide polymorphism (SNP) rs599839 and type 2 diabetes mellitus (T2DM) can affect the occurrence and severity of coronary artery disease (CAD).
Our aim was to investigate how T2DM and the rs599839 variant affected serum lipid levels and the degree of CAD patients' coronary artery stenosis. rs599839 polymorphism genotyping was done on Saudi patients with coronary angiography performed previously. Patients enrolled were divided into group A (360 DM patients), group B (225 DM patients with CAD), and group C (190 healthy volunteers as control).
Individuals with diabetes and CAD who possessed the GG genotype in rs599839 exhibited markedly reduced means of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG; 224.5, 116.2, and 221.4 versus 251.6, 131.3, and 261.7 mg/dl, =0.003, 0.007, and 0.025, respectively) than AA genotype. The odds ratio and the confidence interval of 95% for G allele carriers of rs599839 were OR = 0.62, 95% CI: 0.41-0.82, and =0.003, among diabetic patients with CAD.
In patients with diabetic CAD, the locus 1p13.3 polymorphism rs599839 was found to be substantially correlated with serum lipid levels. Furthermore, among Saudi patients with diabetes, the G allele of rs599839 variant lowers the CAD risk.
冠心病可能受到多种遗传和非遗传因素的影响。单核苷酸多态性（SNP）rs599839 和 2 型糖尿病（T2DM）可影响冠心病（CAD）的发生和严重程度。
我们的目的是研究 T2DM 和 rs599839 变异如何影响血清脂质水平以及 CAD 患者冠状动脉狭窄程度。对以前进行过冠状动脉造影的沙特患者进行 rs599839 多态性基因分型。纳入的患者分为 A 组（360 例 DM 患者）、B 组（225 例 DM 合并 CAD 患者）和 C 组（190 例健康志愿者作为对照组）。
携带 rs599839 中 GG 基因型的糖尿病合并 CAD 个体的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）平均值明显降低（224.5、116.2 和 221.4 与 251.6、131.3 和 261.7mg/dl，=0.003、0.007 和 0.025），而非 AA 基因型。rs599839 中 G 等位基因携带者的优势比（OR）和 95%置信区间（CI）为 0.62、95%CI：0.41-0.82，且=0.003，在患有 CAD 的糖尿病患者中。
在患有糖尿病 CAD 的患者中，发现 1p13.3 位 rs599839 多态性与血清脂质水平密切相关。此外，在沙特阿拉伯的糖尿病患者中，rs599839 变异的 G 等位基因降低了 CAD 风险。
