[具体基因名称]的基因变异与心血管疾病之间的关联：一项系统综述和荟萃分析。
Association between Genetic Variants of and Cardiovascular Diseases: A Systematic Review and Meta-Analysis.
作者信息
Castillo-Avila Rosa Giannina, González-Castro Thelma Beatriz, Tovilla-Zárate Carlos Alfonso, Martínez-Magaña José Jaime, López-Narváez María Lilia, Juárez-Rojop Isela Esther, Arias-Vázquez Pedro Iván, Borgonio-Cuadra Verónica Marusa, Pérez-Hernández Nonanzit, Rodríguez-Pérez José Manuel
机构信息
División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa 86100, Mexico.
División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez 86205, Mexico.
出版信息
J Cardiovasc Dev Dis. 2023 Feb 21;10(3):91. doi: 10.3390/jcdd10030091.
A cluster of three genes , , and has been associated with cardiovascular diseases. Thus, the aim of this study was (i) to perform a systematic review and updated meta-analysis of the association of three polymorphisms (rs646776, rs599839, and rs464218) of this cluster with cardiovascular diseases, and (ii) to explore by PheWAS signals of the three SNPs in cardiovascular diseases and to evaluate the effect of rs599839 with tissue expression by in silico tools. Three electronic databases were searched to identify eligible studies. The meta-analysis showed that the rs599839 (allelic OR 1.19, 95% CI 1.13-1.26, dominant OR 1.22, 95% CI 1.06-1.39, recessive OR 1.23, 95% CI 1.15-1.32), rs646776 (allelic OR 1.46, 95% CI 1.17-1.82) polymorphisms showed an increased risk for cardiovascular diseases. PheWas analysis showed associations with coronary artery disease and total cholesterol. Our results suggest a possible involvement of the cluster variants in the risk association of cardiovascular diseases, particularly coronary artery disease.
一组三个基因，即[基因名称1]、[基因名称2]和[基因名称3]，已被证实与心血管疾病有关。因此，本研究的目的是：（i）对该基因簇的三个多态性位点（rs646776、rs599839和rs464218）与心血管疾病的关联进行系统综述和更新的荟萃分析；（ii）通过全基因组关联研究（PheWAS）探索这三个单核苷酸多态性（SNP）在心血管疾病中的信号，并利用计算机工具评估rs599839对组织表达的影响。检索了三个电子数据库以确定符合条件的研究。荟萃分析表明，rs599839（等位基因优势比1.19，95%置信区间1.13 - 1.26，显性模型优势比1.22，95%置信区间1.06 - 1.39，隐性模型优势比1.23，95%置信区间1.15 - 1.32）、rs646776（等位基因优势比1.46，95%置信区间1.17 - 1.82）多态性与心血管疾病风险增加相关。全基因组关联研究分析显示与冠状动脉疾病和总胆固醇有关。我们的结果表明，[基因簇名称]基因簇变异可能参与心血管疾病的风险关联，尤其是冠状动脉疾病。
Zotero 插件