Tylman Michal Rogowski, Narbutt Joanna, Fracczak Malgorzata, Sysa-Jedrzejowska Anna, Lesiak Aleksandra
Michal Rogowski-Tylman, MD, Department of Dermatology, Medical University of Lodz , Pl. Hallera 1, 94-417 Lodz, Poland;
Acta Dermatovenerol Croat. 2015;23(1):23-7.
Assessment of individual photosensitivity by determining the minimal erythema dose (MED) is commonly accepted. MED objectively describes a single individual response to the irradiation of skin with a particular wavelength (UVB, UVA). Pigment protection factor (PPF) is an objective value to measure skin type. The aim of the project was to analyze PPF values in the population of Lodz and the relationship between PPF, skin phototype, and individual MED. The study was conducted on the group of 270 volunteers: 130 men and 140 women, mean age 28.5 years (OS + 9.66) with either skin phototype II or III, as defined by Fitzpatrick Skin Phototype Classification. Phototesting of each volunteer was undertaken with an increasing dose series (UVB radiation) on six squares (1×1 cm) on the skin of the back. The MED was defined as a perceptible erythema 24 hours later. Starting dose was determined by history, physical examination, and phototype ranged from 0.03-0.07 J/cm2. PPF was measured by a skin reflectance meter UV Optimize 555. The mean MED value was 0.15 J/cm2 and the PPF value was 6.15. A positive correlation between the MED value and PPF (R=0.38; P<0.001), and a positive correlation between phototype and MED and PPF (P< 0.001) were found. Both determination of MED and PPF are objective methods of photosensitivity assessment, but PPF determination is an easy and non-invasive method.
通过确定最小红斑量（MED）来评估个体光敏性已被广泛接受。MED客观地描述了个体皮肤对特定波长（UVB、UVA）照射的反应。色素保护因子（PPF）是衡量皮肤类型的一个客观指标。该项目的目的是分析罗兹市人群的PPF值以及PPF、皮肤光型和个体MED之间的关系。研究对象为270名志愿者：130名男性和140名女性，平均年龄28.5岁（标准差+9.66），皮肤光型为Fitzpatrick皮肤光型分类所定义的II型或III型。对每位志愿者背部皮肤上的六个正方形区域（1×1厘米）进行递增剂量系列（UVB辐射）的光测试。MED定义为24小时后可察觉到的红斑。起始剂量根据病史、体格检查和光型确定，范围为0.03 - 0.07 J/cm²。PPF通过皮肤反射仪UV Optimize 555进行测量。平均MED值为0.15 J/cm²，PPF值为6.15。发现MED值与PPF之间呈正相关（R = 0.38；P < 0.001），光型与MED和PPF之间也呈正相关（P < 0.001）。MED和PPF的测定都是评估光敏性的客观方法，但PPF的测定是一种简单且非侵入性的方法。
