Cheng Ying-Chih, Liang Chun-Mao, Liu Hsing-Cheng
*Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital; and †Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.
Clin Neuropharmacol. 2015 May-Jun;38(3):112-3. doi: 10.1097/WNF.0000000000000076.
Serotonin syndrome is a potentially fatal complication that usually occurs in the combination use of several serotonergic agents. We presented a patient with major depressive disorder under the treatment of bupropion, trazodone, and quetiapine. Serotonin syndrome developed soon after she received the first session of electroconvulsive therapy (ECT).
This study is a case report.
A 70-year-old female with major depressive disorder developed serotonin syndrome after the first session of ECT in combination with bupropion, trazodone, and quetiapine. Serotonin syndrome did not reappear in the subsequent ECT treatment while in the treatment with different therapeutic agents.
The superimposing effect of ECT in conjunction with serotonergic agents might contribute to the development of serotonin syndrome.
血清素综合征是一种潜在的致命并发症，通常发生在几种血清素能药物联合使用时。我们报告了一名患有重度抑郁症的患者，正在接受安非他酮、曲唑酮和喹硫平治疗。她在接受首次电休克治疗（ECT）后不久就出现了血清素综合征。
本研究为病例报告。
一名70岁患有重度抑郁症的女性在首次ECT联合安非他酮、曲唑酮和喹硫平治疗后出现血清素综合征。在后续使用不同治疗药物的ECT治疗中，血清素综合征未再次出现。
ECT与血清素能药物的叠加效应可能导致血清素综合征的发生。
