• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

造血祖细胞异质性的系统图谱

Systems mapping for hematopoietic progenitor cell heterogeneity.

作者信息

Zhou Linghua, Shen Yong, Jiang Libo, Yin Danni, Guo Jingxin, Zheng Hui, Sun Hao, Wu Rongling, Guo Yunqian

机构信息

Center for Computational Biology, Beijing Forestry University, Beijing, People's Republic of China.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, People's Republic of China.

出版信息

PLoS One. 2015 May 13;10(5):e0126937. doi: 10.1371/journal.pone.0126937. eCollection 2015.

DOI:10.1371/journal.pone.0126937
PMID:25970338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4430299/
Abstract

Cells with the same genotype growing under the same conditions can show different phenotypes, which is known as "population heterogeneity". The heterogeneity of hematopoietic progenitor cells has an effect on their differentiation potential and lineage choices. However, the genetic mechanisms governing population heterogeneity remain unclear. Here, we present a statistical model for mapping the quantitative trait locus (QTL) that affects hematopoietic cell heterogeneity. This strategy, termed systems mapping, integrates a system of differential equations into the framework for systems mapping, allowing hypotheses regarding the interplay between genetic actions and cell heterogeneity to be tested. A simulation approach based on cell heterogeneity dynamics has been designed to test the statistical properties of the model. This model not only considers the traditional QTLs, but also indicates the methylated QTLs that can illustrate non-genetic individual differences. It has significant implications for probing the molecular, genetic and epigenetic mechanisms of hematopoietic progenitor cell heterogeneity.

摘要

具有相同基因型的细胞在相同条件下生长时可表现出不同的表型，这被称为“群体异质性”。造血祖细胞的异质性对其分化潜能和谱系选择有影响。然而，控制群体异质性的遗传机制仍不清楚。在此，我们提出了一种用于定位影响造血细胞异质性的数量性状基因座（QTL）的统计模型。这种策略被称为系统定位，它将一个微分方程系统整合到系统定位框架中，从而能够检验关于遗传作用与细胞异质性之间相互作用的假设。已设计出一种基于细胞异质性动力学的模拟方法来测试该模型的统计特性。该模型不仅考虑了传统的QTL，还指出了能够阐明非遗传个体差异的甲基化QTL。它对于探究造血祖细胞异质性的分子、遗传和表观遗传机制具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/530a432ef9c0/pone.0126937.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/99af9ec22569/pone.0126937.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/e29db59277f5/pone.0126937.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/37ab587ea86b/pone.0126937.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/525dd0b3e793/pone.0126937.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/9a57f5f4f476/pone.0126937.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/530a432ef9c0/pone.0126937.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/99af9ec22569/pone.0126937.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/e29db59277f5/pone.0126937.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/37ab587ea86b/pone.0126937.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/525dd0b3e793/pone.0126937.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/9a57f5f4f476/pone.0126937.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d840/4430299/530a432ef9c0/pone.0126937.g006.jpg

相似文献

1
Systems mapping for hematopoietic progenitor cell heterogeneity.造血祖细胞异质性的系统图谱
PLoS One. 2015 May 13;10(5):e0126937. doi: 10.1371/journal.pone.0126937. eCollection 2015.
2
A mathematical framework for functional mapping of complex phenotypes using delay differential equations.使用时滞微分方程对复杂表型进行功能映射的数学框架。
J Theor Biol. 2011 Nov 21;289:206-16. doi: 10.1016/j.jtbi.2011.08.002. Epub 2011 Aug 22.
3
Equivalence of three score tests for association mapping of quantitative trait loci under selective genotyping.基于选择性基因分型的数量性状基因座关联作图的三种评分检验的等效性。
Genet Epidemiol. 2010 Jul;34(5):522-7. doi: 10.1002/gepi.20498.
4
Structural mapping: how to study the genetic architecture of a phenotypic trait through its formation mechanism.结构映射：如何通过表型性状的形成机制来研究其遗传结构。
Brief Bioinform. 2014 Jan;15(1):43-53. doi: 10.1093/bib/bbs067. Epub 2012 Oct 25.
5
Mapping quantitative trait loci in a non-equilibrium population.在非平衡群体中定位数量性状基因座。
Stat Appl Genet Mol Biol. 2010;9:Article32. doi: 10.2202/1544-6115.1578. Epub 2010 Aug 19.
6
A pooling-based approach to mapping genetic variants associated with DNA methylation.一种基于汇集的方法来绘制与DNA甲基化相关的基因变异。
Genome Res. 2015 Jun;25(6):907-17. doi: 10.1101/gr.183749.114. Epub 2015 Apr 24.
7
Statistical model for characterizing epistatic control of triploid endosperm triggered by maternal and offspring QTLs.用于表征由母本和子代数量性状基因座触发的三倍体胚乳上位性控制的统计模型。
Genet Res. 2005 Aug;86(1):65-75. doi: 10.1017/S0016672305007615.
8
Deploying QTL-seq for rapid delineation of a potential candidate gene underlying major trait-associated QTL in chickpea.利用QTL-seq快速确定鹰嘴豆中与主要性状相关的QTL潜在候选基因。
DNA Res. 2015 Jun;22(3):193-203. doi: 10.1093/dnares/dsv004. Epub 2015 Apr 27.
9
Genome-wide association mapping including phenotypes from relatives without genotypes.全基因组关联图谱绘制，包括来自无基因型亲属的表型数据。
Genet Res (Camb). 2012 Apr;94(2):73-83. doi: 10.1017/S0016672312000274.
10
Functional mapping of human growth trajectories.人类生长轨迹的功能映射。
J Theor Biol. 2009 Nov 7;261(1):33-42. doi: 10.1016/j.jtbi.2009.07.020. Epub 2009 Jul 24.

引用本文的文献

1
Digital Microfluidics for Manipulation and Analysis of a Single Cell.用于单细胞操作与分析的数字微流控技术
Int J Mol Sci. 2015 Sep 15;16(9):22319-32. doi: 10.3390/ijms160922319.

本文引用的文献

1
Signalling pathways that control vertebrate haematopoietic stem cell specification.控制脊椎动物造血干细胞特化的信号通路。
Nat Rev Immunol. 2013 May;13(5):336-48. doi: 10.1038/nri3443.
2
Concise review: erythroid versus myeloid lineage commitment: regulating the master regulators.简明综述：红系与髓系谱系的定向分化：调控主调控因子。
Stem Cells. 2013 Jul;31(7):1237-44. doi: 10.1002/stem.1379.
3
Dynamic semiparametric Bayesian models for genetic mapping of complex trait with irregular longitudinal data.动态半参数贝叶斯模型在不规则纵向数据复杂性状遗传定位中的应用。
Stat Med. 2013 Feb 10;32(3):509-23. doi: 10.1002/sim.5535. Epub 2012 Aug 17.
4
Dynamic modeling of genes controlling cancer stem cell proliferation.控制癌症干细胞增殖的基因的动态建模。
Front Genet. 2012 May 22;3:84. doi: 10.3389/fgene.2012.00084. eCollection 2012.
5
Systems mapping: how to improve the genetic mapping of complex traits through design principles of biological systems.系统映射：如何通过生物系统的设计原则改进复杂性状的基因定位
BMC Syst Biol. 2011 May 27;5:84. doi: 10.1186/1752-0509-5-84.
6
A dynamic model for functional mapping of biological rhythms.生物节律功能映射的动态模型。
J Biol Dyn. 2011 Jan;5(1):84-101. doi: 10.1080/17513758.2010.491558.
7
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines.DNA 甲基化模式与 HapMap 细胞系中的遗传和基因表达变异相关联。
Genome Biol. 2011;12(1):R10. doi: 10.1186/gb-2011-12-1-r10. Epub 2011 Jan 20.
8
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.造血祖细胞向谱系定向分化的全甲基化组图谱
Nature. 2010 Sep 16;467(7313):338-42. doi: 10.1038/nature09367. Epub 2010 Aug 15.
9
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain.大量的 DNA 甲基化和基因表达数量性状基因座存在于人类大脑中。
PLoS Genet. 2010 May 13;6(5):e1000952. doi: 10.1371/journal.pgen.1000952.
10
Functional clustering of periodic transcriptional profiles through ARMA(p,q).通过 ARMA(p,q) 对周期性转录谱进行功能聚类。
PLoS One. 2010 Apr 16;5(4):e9894. doi: 10.1371/journal.pone.0009894.