Zagorchev Lyubomir, Meyer Carsten, Stehle Thomas, Wenzel Fabian, Young Stewart, Peters Jochen, Weese Juergen, Paulsen Keith, Garlinghouse Matthew, Ford James, Roth Robert, Flashman Laura, McAllister Thomas
1 Philips Research North America , Briarcliff Manor, New York.
2 Thayer School of Engineering, Dartmouth College , Hanover, New Hampshire.
J Neurotrauma. 2016 Jan 1;33(1):29-34. doi: 10.1089/neu.2014.3831. Epub 2015 Jul 23.
Conventional structural imaging is often normal after mild traumatic brain injury (mTBI). There is a need for structural neuroimaging biomarkers that facilitate detection of milder injuries, allow recovery trajectory monitoring, and identify those at risk for poor functional outcome and disability. We present a novel approach to quantifying volumes of candidate brain regions at risk for injury. Compared to controls, patients with mTBI had significantly smaller volumes in several regions including the caudate, putamen, and thalamus when assessed 2 months after injury. These differences persisted but were reduced in magnitude 1 year after injury, suggesting the possibility of normalization over time in the affected regions. More pronounced differences, however, were found in the amygdala and hippocampus, suggesting the possibility of regionally specific responses to injury.
轻度创伤性脑损伤（mTBI）后，传统结构成像通常显示正常。需要有结构神经影像生物标志物来促进对较轻损伤的检测，监测恢复轨迹，并识别那些功能预后不良和残疾风险高的患者。我们提出了一种新方法来量化有损伤风险的候选脑区体积。与对照组相比，mTBI患者在受伤后2个月进行评估时，包括尾状核、壳核和丘脑在内的几个区域体积明显较小。这些差异持续存在，但在受伤1年后幅度减小，表明受影响区域有可能随时间恢复正常。然而，在杏仁核和海马体中发现了更明显的差异，提示对损伤可能存在区域特异性反应。
